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IRCT20200411047016N1 IRCT 2020-05-31 Mazandaran University of Medical Sciences The effect of Stopcivir syrup in patients with COVID-19 Stopcivir syrup Evaluating efficacy and safety of Stopcivir (Zataria multiflora Boiss+ Alium Sativum+ Heracleum persicum+ Satureja hortensis+ Dianthus+ Foeniculum vulgare+ opium) syrup on length of hospitalization in patients with COVID-19 2020-04-05 anticipated 150 Complete https://irct.ir/trial/47044 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be by blocking randomization (quadruple random blocks). Which is provided by statistical software. Randomization units are individuals. 150 outpatients referred to the hospital emergency department are randomly assigned to one of the two intervention and control groups. This study is a two-course method and patients in the intervention group will receive the intervention drug in addition to the routine treatment, but in the patient control group, they will receive the placebo along with the routine treatment, Blinding description: To blind the study, the drugs are packaged with special tags with double-digit codes so that only the final evaluator, who is a physician, is aware of the type of medication that patients are receiving. Also, in order not to inform the patient, the placebo is given to the control group. Therefore, patients are not aware of the type of medication they are receiving. 3 COVID- 19. Intervention 1: Intervention group: In this study, the content of specific ratios of garlic, Lamiaceae, Heracleum persicum, Dianthus, Satureja hortensis plus a little opium in an alcohol-based solvent will be prepared and used as an adjunctive or concomitant medication alongside other routine medicine to treat patients with covid 19. Both groups will receive standard treatment. The dosage of the syrup for the first two days is 10 cc every 4 hours and the next two days is 10 cc every 6 hours, which is given to the patient by the ward nurse and is monitored. Intervention 2: Control group: The other group receives the placebo. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information at this time.
public Seyedeh Sedigheh Yousefi
Touba Clinic; Khazar Boulevard; Khazar Square
Sari Iran (Islamic Republic of) 48168-95474 +98 11 3324 4893 s.yousefi@mazums.ac.ir Mazandaran University of Medical Sciences scientific Seyde Sedighe Yousefi
Touba Clinic; Khazar Boulevard; Khazar Square
Sari Iran (Islamic Republic of) 48168-95474 +98 11 3324 4893 s.yousefi@mazums.ac.ir Mazandaran University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) The definitive case of covid 19 based on laboratory confirmation Diagnosis of covid 19 based on CT or chest radiography Patients between 18-75 years 18 years 75 years Both The presence of comorbidities (sever renal failure, sever liver failure, CHF, major cerebrovascular and cardiovascular disease, chronic lung disease, malignancy, immune system diseases including AIDS, encephalopathy) Pregnancy and lactation History of allergies to herbal drugs Crisis and severe cases B34.2 Coronavirus infection, unspecified Treatment - Drugs Treatment - Drugs Intervention group: In this study, the content of specific ratios of garlic, Lamiaceae, Heracleum persicum, Dianthus, Satureja hortensis plus a little opium in an alcohol-based solvent will be prepared and used as an adjunctive or concomitant medication alongside other routine medicine to treat patients with covid 19. Both groups will receive standard treatment. The dosage of the syrup for the first two days is 10 cc every 4 hours and the next two days is 10 cc every 6 hours, which is given to the patient by the ward nurse and is monitored. Control group: The other group receives the placebo. Length of hospitalization. Timepoint: Hospitalization time and Hospital discharge time. Method of measurement: Check List. Shortness of breath. Timepoint: Variable will be completed in the form of a checklist at the beginning of the Hospitalization and daily until the end of hospitalization. Method of measurement: Check list. Oxygen saturation. Timepoint: Variable will be completed in the form of a checklist at the beginning of the Hospitalization and daily until the end of hospitalization. Method of measurement: Check list. Mazandaran University of Medical Sciences Approved 2020-04-05 Ethics committee of Mazandaran University of Medical Sciences Deputy of Research and Technology of Mazandaran University of Medical Sciences, Teacher Street, Teacher's Square Sari Mazandaran Iran (Islamic Republic of)