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IRCT20200413047059N1 IRCT 2020-11-09 Esfahan University of Medical Sciences Comparative effect of chlorhexidine mouthwash with plant-based mouthwash in the prevention of pneumonia A comparative study of chlorhexidine mouthwash with plant-based mouthwash in the prevention of ventilator-related pneumonia in patients admitted to the intensive care unit 2018-07-23 anticipated 80 Complete https://irct.ir/trial/47206 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simply put, the individual was divided into two groups of 40 by referring to the hospital and the relevant department and using the SPSS statistical software version 23, Blinding description: In order to observe blindness, the study of patients and the person who determines the final result of the study (the patient's doctor) will not be aware of the groups under study and the study will be of the blind type. 2 Ventilate-related pneumonia. Intervention 1: Intervention group: First, treatment with chlorhexidine is 0.2%. The frequency, timing, and manner of mouth washing in this group will be performed in the same way, three times a day for 5 days, every eight hours. First, a sterile gauze wrap is wrapped around an abscess and then soaked in a mouthwash, and like a toothbrush, all areas of the mouth, gums, tongue, throat, and teeth are washed for 6 minutes. The amount of chlorination in each wash is 10 cc and in the case of butter, the consumption of 25-20 drops per half cup of water is dissolved. Intervention 2: Intervention group: Dine mouthwash made by Dineh Pharmaceutical Company. In the second group, treatment will begin with a mouthwash. Frequency, timing, and method of mouth washing in both groups will be done in the same way and three times a day for 5 days, every eight hours. First, a sterile gauze wrapped around a tongue blade and then soaked in mouthwash, and like a toothbrush, all areas of the mouth, gums, tongue, throat, and teeth are washed for 6 minutes. The amount of chlorination in each wash is 10 cc and in the case of butter, the consumption of 25-20 drops per half cup of water is dissolved. Yes - There is a plan to make this available What will be shared: A part of the data such as information about the main consequence When: Starting access in the fall of 2020 To whom: Researchers Conditions: In case of further studies and changes in different doses and materials, the use of documents is allowed. Where to obtain: Submit a request by e-mail to the author and provide a title related to the study How to obtain: The request will be sent by e-mail and the documents will be sent one week after the review. Comments:
public Yeganeh Fatemi
Hezar Jarib St, Isfahan university of medical sciences
Isfahan Iran (Islamic Republic of) 81746-73461 +98 31 5550 0111 ygn.ftm1994@gmail.com Esfahan University of Medical Sciences scientific Yeganeh Fatemi
Hezar Jerib St, Isfahan university of medical sciences
Isfahan Iran (Islamic Republic of) 81746-73461 +98 31 5550 0111 ygn.ftm1994@gmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Age over 18 years Requires mechanical ventilation for at least 48 hours Do not use the chip pipe before entering the intensive care unit No specific lesions in and around the mouth Lack of safety defects Do not take antibiotics before hospitalization No pregnancy Lack of allergy to plant compounds Has natural teeth Free and informed written consent of the patient's companion or guardian to participate in the study 18 years no limit Both J95.851 Ventilator associated pneumonia Treatment - Drugs Treatment - Drugs Intervention group: First, treatment with chlorhexidine is 0.2%. The frequency, timing, and manner of mouth washing in this group will be performed in the same way, three times a day for 5 days, every eight hours. First, a sterile gauze wrap is wrapped around an abscess and then soaked in a mouthwash, and like a toothbrush, all areas of the mouth, gums, tongue, throat, and teeth are washed for 6 minutes. The amount of chlorination in each wash is 10 cc and in the case of butter, the consumption of 25-20 drops per half cup of water is dissolved. Intervention group: Dine mouthwash made by Dineh Pharmaceutical Company. In the second group, treatment will begin with a mouthwash. Frequency, timing, and method of mouth washing in both groups will be done in the same way and three times a day for 5 days, every eight hours. First, a sterile gauze wrapped around a tongue blade and then soaked in mouthwash, and like a toothbrush, all areas of the mouth, gums, tongue, throat, and teeth are washed for 6 minutes. The amount of chlorination in each wash is 10 cc and in the case of butter, the consumption of 25-20 drops per half cup of water is dissolved. Ventilator-related pneumonia. Timepoint: At the beginning of the study and 3 weeks after using two mouthwashes. Method of measurement: A microbial infection of the lung that occurs more than 48 hours after mechanical ventilation with a ventilator. Diagnosis of this type of pneumonia is based on the symptoms of pulmonary infection (including: purulent discharge, fever and leukocytosis), bacteriological evidence of pulmonary infection, and evidence of lung infection on specific radiographic images. Esfahan University of Medical Sciences Approved 2020-04-07 National Committee for Ethics in Biomedical Research Hezar Jarib St. Isfahan University of Medical Sciences and Health Services Isfahan Isfehan Iran (Islamic Republic of)