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IRCT20190418043307N1 IRCT 2020-05-17 Deputy Dean of Research and Technology, Ilam university of medical science Effect of selenium on covid-19 disease Investigating the effectiveness of selenium on recovery of hospitalized patients with COVID-19 2020-04-26 anticipated 100 Complete https://irct.ir/trial/47209 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The first phase involves the screening process of potential patients by the researcher to identify the eligibility to participate based on the study inclusion and exclusion criteria. The research assistant will contact eligible participants for enrollment. Those patients who agree to take part in the study will be provided with the information sheet and written consent form before baseline assessment at enrolment. 100 Patients with Covid-19 will be randomized sequentially at the time they provided a baseline assessment. Randomization will be generated by permuted block randomization with allocation concealment. Participants will be divided into intervention or control groups. The control group will receive only the standard protocol treatment, but the intervention group will receive the selenium for 2 weeks in addition to the standard protocol treatment. 3 covid-19. Intervention 1: Intervention group: In addition to the standard protocol treatment, patients in the intervention group will receive 200 micrograms selenium daily for at least 2 weeks. Routine blood tests, the need for hospitalization, and the mortality rate will be measured as the study outcomes. Intervention 2: Control group: Participants in the control group will receive the standard protocol treatment. standard protocol treatment consists of 400 mg Hydroxychloroquine twice daily on day one, followed by 200 mg twice per day. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I haven't decided on that yet.
public Ali Nazari
Modares Avenue
Ilam Iran (Islamic Republic of) 6931854919 +98 84 3222 3721 nazari-a@medilam.ac.ir Ilam University of Medical Sciences scientific Ali Nazari
Modares Avenue
Ilam Iran (Islamic Republic of) 6931854919 +98 84 3222 3721 nazari-a@medilam.ac.ir Ilam University of Medical Sciences Iran (Islamic Republic of) Diagnosis of COVID-19 by RT-PCR test Respiratory rate above 30 bar per minute Percentage of peripheral blood oxygen saturation less than 90% Relative oxygen depletion ratio to arterial oxygen saturation less than 300 mm Hg Interloquin six blood levels higher Abnormally age over 18 years 18 years 65 years Both chronic kidney disease acute kidney failure Pregnancy or lactation History of drug allergy Pneumonia caused by H influenza, viral infections, bacterial infections, fungi; and other noninfectious types of pneumonia Chronic liver disease history of latent or active tuberculosis patients with acquired immunodeficiency syndrome U07.1 COVID-19, virus identified Treatment - Drugs Treatment - Drugs Intervention group: In addition to the standard protocol treatment, patients in the intervention group will receive 200 micrograms selenium daily for at least 2 weeks. Routine blood tests, the need for hospitalization, and the mortality rate will be measured as the study outcomes. Control group: Participants in the control group will receive the standard protocol treatment. standard protocol treatment consists of 400 mg Hydroxychloroquine twice daily on day one, followed by 200 mg twice per day. Ferritin changes. Timepoint: Daily. Method of measurement: Laboratory. Platelet. Timepoint: Daily. Method of measurement: Laboratory. CRP. Timepoint: Daily. Method of measurement: Laboratory. WBC changes. Timepoint: Daily. Method of measurement: Laboratory. Reduced mortality. Timepoint: Day 1 to 14. Method of measurement: Record the time of death. Deputy Dean of Research and Technology, Ilam university of medical science Approved 2020-04-14 Ethics committee of Ilam University of Medical Sciences modares Ave Ilam Ilam Iran (Islamic Republic of)