IRCT20180416039326N13 IRCT 2020-06-15 Esfahan University of Medical Sciences Effect of intranasal dexamethasone on prevention of postoperative nausea and vomiting in hysterectomy Comparative study of the effect of intranasal dexamethasone on prevention of postoperative nausea and vomiting in hysterectomy 2020-06-14 anticipated 70 Complete https://irct.ir/trial/47288 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Random allocation to intervention and control groups using Random allocation software.70 patients who have candidated for elective hysterectomy will divided randomly to intervention group who will recieve nasal dexamethasone (group A) and control group who will recieve nasal normal saline, Blinding description: Anesthesiologist who has no function in collection of dates devides drugs in two groups A and B with same volume and then describes them . In this double-blind clinical trial the patient and the observer who records dates are unware of patients groups and drugs which are being studied but the analyzer is aware. 2-3 Postoperative Nausea and Vomiting. Intervention 1: Intervention group: After receiving 10ml/kg of ringer lactate and pre-oxygenation for patients, the same anesthetic induction was performed including Fentanyl 2mcg / kg, Propofol 2 mg / kg and Atracurium 0.5 to 0.7 mg / kg, midazolam 0.3 to 0.5mcg / kg and the patients underwent mechanical ventilation by mask and ambobag for three minutes. Immediately after intubation, 1 cc of dexamethasone (4mg) was injected in each nostril. Intervention 2: Control group: After receiving 10ml/kg of ringer lactate and pre-oxygenation for patients, the same anesthetic induction was performed including Fentanyl 2mcg / kg, Propofol 2 mg / kg and Atracurium 0.5to 0.7mg / kg, midazolam 0.3to 0.5mcg / kg and the patients underwent mechanical ventilation by mask and ambobag for three minutes. Immediately after intubation, 1 ml of normal saline was injected in each nostril. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information