IRCT20160809029286N6 IRCT 2020-04-29 Joint Reconstruction Research Center Intra-articular vs Intravenous vs combine IVIA Tranexamic Acid in total knee arthroplasty Intra-articular vs Intravenous vs combine IVIA Tranexamic Acid in total knee arthroplasty patients 2017-07-23 anticipated 147 Complete https://irct.ir/trial/47313 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: For randomization, the permuted balanced blocks method was used. In this method, six balanced blocks (1 to 6) were defined regarding the three interventions of the study (A, B, C) including BAC, ACB, ABC, CAB, BCA and CBA . The patients were divided into 49 groups of three patients. The patients’ numbers were inserted from 1 to 147 in a column using MS Excel software. In another column, the group of each patient was inserted, for example: patients 1 to 3 as group 1, patients 4 to 6 as group 2, …, patients 144 to 147 as group 49. In another Excel sheath, the groups were inserted from 1 to 49, and the blocks were inserted across each group from 1 to 6 in order till the end. In the next column, non-repeated random numbers were inserted using the “RANDL()” command. Subsequently, the order of the blocks was randomly changed. According to the block assigned with each group, the intervention regarding each patient was determined. For example, if group 1 is assigned with “CAB”, the interventions were as follows: Patient 1, C; Patient 2, A; Patient 3, B, Blinding description: During the injection of tranexamic acid, the person who does the injection hadn't any information about the study. Patients are not aware of the medication model of injection. Patients are divided into groups by random code designed by the researcher and identified with the patient ID at the time of analysis. 3 Blood Loss after Total Knee Arthroplasty. Intervention 1: Intervention group: 15 mg/kg TXA intra-Articular injection post-operative. Intervention 2: Intervention group: 15 mg/kg TXA intravenous injection before the surgery and performing tourniquet. Intervention 3: Intervention group: TXA was injected in combination of postoperative intra-Articular and preoperative intravenous methods and 15 mg/kg for each method. Yes - There is a plan to make this available What will be shared: En At the end of the study, All data Except Demographics will be published. When: July 2020 To whom: Orthopedic Surgeons Conditions: There are no special conditions Where to obtain: Anyone can request study data by sending an email to the plan executor (َAlireza Moharrami). How to obtain: Within 2 weeks will be answered Comments: -