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IRCT138905024440N1 IRCT 2010-10-11 Vice Chancellor for Research of Dental School, Isfahan University of Medical Sciences A comparison of anesthetic efficacy of combined local anesthetic and ketamine in patients with irreversible pulpitis in the posterior mandibular teeth A comparison of anesthetic efficacy of combined local anesthetic and ketamine in patients with irreversible pulpitis in the posterior mandibular teeth 2010-08-01 anticipated 40 Complete https://irct.ir/trial/4739 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. 2-3 Irreversible pulpitis. Intervention 1: Two dental cartridges of 2% Articaine combined with 20mg of Ketamine. Intervention 2: Two dental cartridges of 2% Articaine combined with 0.2ml normal saline.
public Vahid Sakhaei manesh
Dental School, Isfahan University of Medical Sciences, Hezar Jarib Street
Isfahan Iran (Islamic Republic of) +98 936 552 1098 sakhaei@dnt.mui.ac.ir Dental School, Isfahan University of Medical Sciences scientific Dr. Abbasali Khademi
Hezar Jarib Street
Isfahan Iran (Islamic Republic of) +98 31 1792 2821 a_khademi@dnt.mui.ac.ir Department of Endodontics, Dental School, Isfahan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients aged 18-50 years, in healthy condition (ASA I or ASA II), having a posterior mandibular tooth (premolar or molar tooth) with a vital pulp and diagnosed as irreversible pulpitis, without severe periodontal disease, without any periapical pathological defect as seen in the radiograph of the tooth, without any contraindications for the drugs and substanses used in the study. Exclusion criteria: Patients showing signs of pulp necrosis upon access cavity opening, patients showing any signs or symptoms of allergy or any adverse effects, patients refusing to continue at any stage point. 18 years 50 years Both K04.0 Pulpitis Treatment - Drugs Placebo Two dental cartridges of 2% Articaine combined with 20mg of Ketamine Two dental cartridges of 2% Articaine combined with 0.2ml normal saline Pain. Timepoint: Before and 15 minutes after administration of the local anesthetic. Method of measurement: Visual Analogue Scale (VAS). Pulpal anesthesia. Timepoint: Before and 15 minutes after administration of the local anesthetic. Method of measurement: Pulp tester. Vice Chancellor for Research of Dental School, Isfahan University of Medical Sciences Approved Dental School Ethics Committee, Isfahan University of Medical Sciences Vice Chancellor for Research of Dental School, Isfahan University of Medical Sciences Isfahan Iran (Islamic Republic of)