IRCT20191102045310N1 IRCT 2020-04-28 Tehran University of Medical Sciences Sub-endometrial injection of vasopressin for invasive placenta Sub-endometrial injection of vasopressin to control bleeding in postpartum hysterectomy due to abnormally invasive placenta 2017-03-21 anticipated 60 Complete https://irct.ir/trial/47399 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Type of randomization: simple Randomization unit: individual Randomization tool: envelop Random sequence generation: envelop shuffling Allocation concealment: central randomiation, Blinding description: After providing sufficient explanations and obtaining informed consent, the patients' initial data will be collected, and a distinct date for cesarean section will be determined. Participants will then be randomly assigned into intervention or control groups. For patients, ready-to-inject solutions are provided by the hospital pharmacy. The prepared solution for the intervention group is 20 ml in total, containing 1 ml of vasopressin, equivalent to 5 units, which is diluted in 19 ml of 0.9% normal saline. The solution prepared for the control group will also contain 20 ml of 0.9% normal saline. The only person who knows the contents of the solution is the pharmacist, and doctors do not know the contents of the syringes during the operation. After the intervention, the health care personnel will be also blinded. 3 pregnancy with placenta accreta. Intervention 1: Intervention group: a total of 20 ml, containing 1 ml of vasopressin, equivalent to 5 units, diluted in 19 ml of normal saline 0.9% will be injected sub-endometrially. Intervention 2: Control group: The solution prepared for the control group will also contain 20 ml of 0.9% normal saline which will be injected sub-endometrially. . Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No further information.