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IRCT20150613022681N2 IRCT 2020-04-30 Esfahan University of Medical Sciences Comparison of the effect of chlorhexidine mouthwash and irsha mouthwash drop in the prevention of pulmonary infection in hospitalized patients in the intensive care unit Comparison of the effect of chlorhexidine mouthwash with irsha mouthwash drop on probable ventilator-associated pneumonia in intensive care unit 2019-03-21 anticipated 80 Complete https://irct.ir/trial/47474 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: A total of 80 intubated patients in intensive care unit are enrolled in the study according to inclusion and exclusion criteria and are divided into two groups with blocking method and by Random Allocation Software, Blinding description: Patients are blinded by the type of medication used in the intensive care unit due to their intubation and relaxation, the drugs are also prepared in separate containers with numbers, and the nurse who used the medication for the patients does not know the type of drugs. After collecting the information, it enters the software by numbering, and after performing statistical analysis and completion of the work, the codes are determined. N/A Ventilator associated pneumonia. Intervention 1: Intervention group: washing of mouth and teeths with 10 cc chlorhexidine 0.2% three times of day until 5 days. Intervention 2: Intervention group: washing of mouth and teeths with 20-25 drops irsha 0.2% three times of day until 5 days. No - There is not a plan to make this available Justification or reason for not sharing IPD is Information belongs to government agency
public Babak Alikiai
Shohadaye Sofe St.
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 alikiaiib@med.mui.ac.ir Esfahan University of Medical Sciences scientific Babak Alikiai
Shohadaye Sofe St.
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 alikiaiib@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Age over 18 years Requires mechanical ventilation for at least 48 hours Satisfaction to participate in the study Patients with natural teeth 18 years no limit Both Specify any damage caused by endotracheal intubation. Extubation before 5 days Patient death within 5 days of follow-up J95.851 Ventilator associated pneumonia Prevention Prevention Intervention group: washing of mouth and teeths with 10 cc chlorhexidine 0.2% three times of day until 5 days. Intervention group: washing of mouth and teeths with 20-25 drops irsha 0.2% three times of day until 5 days. Ventilator associated pneumonia incidence. Timepoint: After using the drug on a daily basis up to 5 days. Method of measurement: Clinical pulmonary infection score. Esfahan University of Medical Sciences Approved 2019-11-12 Ethics committee of Isfahan University of Medical Sciences Hezar Jerib Street Isfahan Isfehan Iran (Islamic Republic of)