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IRCT20180425039414N2 IRCT 2020-05-13 Esfahan University of Medical Sciences The effect of zinc on the treatment and clinical course of patients with SARS-cov2 (COVID-19) The effect of zinc on the treatment and clinical course of patients with SARS-cov2 (COVID-19) 2020-04-20 anticipated 80 Complete https://irct.ir/trial/47516 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: 80 patients with covid19, hospitalized in Amin Hospital in Isfahan, who have a case file in the hospital registration system, are randomly assigned to two groups of 40 people using spss computer software and the intervention is randomly assigned. 2-3 SARS-cov2(COVID-19). Intervention 1: Intervention group: Includes 40 patients with COVID-19 which for 5 days, who are given two 200 mg hydroxychloroquine sulfate tablets every 12 hours on the first day and then 200 mg every 12 hours. In addition to the above, zinc tablets with a dose of 220 mg twice a day orally during the patient's hospitalization will be prescribed. Intervention 2: Control group: Includes 40 patients with COVID-19 which for 5 days, who are given two 200 mg hydroxychloroquine sulfate tablets every 12 hours on the first day and then 200 mg every 12 hours. Yes - There is a plan to make this available What will be shared: All information can be shared two months after the results are published. When: Two months after the results are published. To whom: Doctors, nurses, and infectious disease specialists Conditions: To evaluate other complementary therapies and compare their effects with existing COVID-19 therapy Where to obtain: Send email to a.hakamifard@med.mui.ac.ir How to obtain: Two months after the publication of the results, send your email to a.hakamifard@med.mui.ac.ir and write your request clearly. In this case, and finally within a month after receiving the email and the above will be answered. Comments:
public Atousa Hakamifard
Alzahra hospital, Soffeh Ave
Isfahan Iran (Islamic Republic of) 8174755685 +98 31 3668 5555 a.hakamifard@med.mui.ac.ir Esfahan University of Medical Sciences scientific Atousa Hakamifard
Alzahra hospital, Soffeh Ave
Isfahan Iran (Islamic Republic of) 8174785664 +98 31 3668 5555 a.hakamifard@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) 18 years of age or older Diagnosis of COVID-19 by RT PCR and CT scan of the lungs Blood oxygen levels are between 90 and 93 percent Breathing rate between 20 and 24 per minute Heart rate between 100 and 130 beats per minute 18 years no limit Both Intubation(mechanical ventilation) Blood oxygen level below 90% Breathing rate equal to 30 or more per minute Allergic reaction to drugs Shortness of breath caused by cardiogenic pulmonary edema Pregnancy and lactation History of oxygen therapy at home Patients with end stage, lung, malignant, G6PD deficiency, diabetic ketoacidosis, cardiac arrhythmia U07.1 COVID-19, virus identified Treatment - Drugs Treatment - Drugs Intervention group: Includes 40 patients with COVID-19 which for 5 days, who are given two 200 mg hydroxychloroquine sulfate tablets every 12 hours on the first day and then 200 mg every 12 hours. In addition to the above, zinc tablets with a dose of 220 mg twice a day orally during the patient's hospitalization will be prescribed. Control group: Includes 40 patients with COVID-19 which for 5 days, who are given two 200 mg hydroxychloroquine sulfate tablets every 12 hours on the first day and then 200 mg every 12 hours. Clinical response. Timepoint: During hospitalization. Method of measurement: Cessation of fever, improvement of shortness of breath, reduction of cough, blood oxygenation (SaO2) and hemodynamic parameters. Mortality. Timepoint: During hospitalization. Method of measurement: Count the number of dead patients. Hospital stay. Timepoint: During hospitalization. Method of measurement: Count the number of hospital days to improve clinical symptoms. Esfahan University of Medical Sciences Approved 2020-04-03 Ethics committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Soffeh Ave Isfahan Isfehan Iran (Islamic Republic of)