IRCT20200426047213N1 IRCT 2020-05-14 Tehran Islamic Azad university of Medical Sciences Efficacy of umbilical cord Mesenchymal Stem Cells on patients with neuromuscular disorders Assessment of Efficacy of umbilical cord derived mesenchymal Stem Cells transplantation on movement improvement in patients with neuromuscular disorders 2019-10-23 anticipated 120 Complete https://irct.ir/trial/47545 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Patients are divided into 4 groups of 30 patients (15 for Test group and 15 for control patients).The first group of patients with Duchenne and Becker muscular dystrophy based on genetic testing, the second group of neuropathic patients such as Spinal Muscular Atrophy and Charcot-Marie-Thoth disease based on genetic testing, the third group of patients with other types of muscular dystrophy such as Limb girdle Muscular Dystrophy and Congenital muscular dystrophy Based on genetic testing, the fourth group are other inherited myopathies such as congenital myopathy and congenital myasthenic syndrome, Randomization description: In order to randomly assign to the two groups of test and control, the block random division method with four blocks was used. In this way, the letter A was assigned to the test group and the letter B to the control group. In four blocks with letters A and B, the six modes AABB, BBAA, ABAB, BABA, ABBA, BAAB were written on separate sheets and thrown inside a container and accidentally removed one of these sheets from the container. And the composition written on it was noted and again "that sheet was thrown into the container." Because the sample size in this study was 30 patients, this operation was repeated eight times, and each time the composition written on each sheet was written in the sequence of the composition written on the previous sheet. Then, one letter from one to thirty letters was assigned to each of the letters in order, and each letter was placed in an envelope and the number was written on the envelope. Each time the disease was selected, one of the envelopes was opened in order of the number written on the envelope, and it was determined that the patient should be in the test or control group. 3 Condition 1: Dystrophinopathy(Duchenne muscular dystrophy, Becker muscular dystrophy). Condition 2: Spinal muscular atrophy. Condition 3: other Myopathy (Congenital myopathy, Congenital myasthenic syndrome). Condition 4: Charcot-Marie-Tooth). Intervention 1: Intervention group: In intervention group or test group the transplantation or injection of mesenchymal stem cell will be done. In this study the site of transplantation is in operation room of Farhikhtegan subspecialty hospital. Before the stem cell injection, the patient needs to be hospitalized for one day. For each patient, four injections are given at the first injection, two weeks later, one month later, and again three months intervals. 3 million per kilogram body weight mesenchymal stem cell are transplanted into the patient's weak muscles under sedation conditions and under ultrasound guidance. After the umbilical cord mesenchymal cell injection, the patient is hospitalized and monitored for 24 hours. Intervention 2: Control group: For each patient in Test group, there is a patient with same genetic mutation in control group. There is no intervention in control group. After determined intervention the clinical feature of these two group will be compared. Yes - There is a plan to make this available What will be shared: After 12 months we will publish the analysis of datas When: After 12 months we will publish the analysis of datas To whom: All interested researchers Conditions: After 12 months we will publish the analysis of datas Where to obtain: Mohammadkazem Bakhshandeh How to obtain: Official request from research department Comments: