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IRCT20200424047185N1 IRCT 2020-05-26 Zahedan University of Medical Sciences The Effect of Desmopressin on The Post Operative Bleeding The Effect of Desmopressin on The Post Operative Bleeding in Patients Undergoing Open Heart Surgery 2020-03-20 anticipated 194 Complete https://irct.ir/trial/47562 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Easy (available) sampling, in which two groups of age and sex will be matched and matched frequently using stratified randomization. The explanation of this method is that after entering the study, patients are divided into two groups, male and female, which in each group of patients are divided into two categories of patients under 50 years of age and over 50 years of age. Depending on the accident, individuals will be assigned to two intervention groups and a control group, Blinding description: An expert who will be responsible for measuring bleeding reduction will be blinded in terms of knowledge of the type of medication. Desmopressin and normal saline sprays are given to each of the patients in the intervention or control group 30 minutes before the operation, respectively, by the anesthesiologist in the operating room 30 minutes before the start of the operation. The pharmacist and the person measuring the patient's bleeding at ICUOH are the same for both groups and do not know what group the patient is in and what medication he or she has received (they are blind). 3 Bleeding - open heart surgery - Desmopressin. Intervention 1: Intervention group: Desmopressin is an artificial analogue of vasopressin group. 0.3 micrograms per kilogram is given to each patient of the intervention group 30 minutes before the operation. Intervention 2: Control group: Sodium chloride solution is 0.9% injectable, a sterile, non-febrile solution, free of preservatives and isotonic, and contains 9 mg of sodium chloride per ml. 0.3 micrograms per kilogram is given to each patient in the control group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Azadiahmadabadi Changiz
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Zahedan Iran (Islamic Republic of) 9816743111 +98 54 3329 5570 kianihamed93@yahoo.com Zahedan University of Medical Sciences scientific Azadiahmadabadi Changiz
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Zahedan Iran (Islamic Republic of) 9816743111 +98 54 3329 5570 kianihamed93@yahoo.com Zahedan University of Medical Sciences Iran (Islamic Republic of) Candidate for open heart surgery no limit no limit Both Blood coagulation disease Treatment - Surgery Prevention Intervention group: Desmopressin is an artificial analogue of vasopressin group. 0.3 micrograms per kilogram is given to each patient of the intervention group 30 minutes before the operation. Control group: Sodium chloride solution is 0.9% injectable, a sterile, non-febrile solution, free of preservatives and isotonic, and contains 9 mg of sodium chloride per ml. 0.3 micrograms per kilogram is given to each patient in the control group. Postoperative bleeding. Timepoint: Measure the patient's bleeding rate two, six, eight, twelve, and twenty-four hours after surgery. Method of measurement: The amount of blood in the Chest Bottle is in milliliters. Zahedan University of Medical Sciences Approved 2020-04-21 Ethics Committee of Zahedan University of Medical Sciences Dr. Hesabi Square, Medical Sciences Campus Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)