]>
IRCT20200502047261N1 IRCT 2023-02-20 Tehran University of Medical Sciences Intrauterine delivery of Dexamethasone for repeated implantation failure: a RCT Intrauterine delivery of Dexamethasone for repeated implantation failure: a RCT 2019-05-22 anticipated 60 Complete https://irct.ir/trial/47599 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Based on random sampling, patients are divided into intervention and control groups, Blinding description: For patients who have the criteria to enter the study, after obtaining informed consent, according to the decision of the ethics committee of Tehran University of Medical Sciences, a questionnaire will be completed and they are unaware of the allocation of the study group. N/A Patients with repeated implantation failure. Intervention 1: Control group: In the control group, on days 9 and 12, normal intrauterine injection of 600µL sterile saline (5 mg / ml) is performed with a fetal transfer catheter. Intervention 2: Intervention group: In patients in the 9 and 12 days of intramuscular injection of dexamethasone 600µL (5 mg / ml) with a fetal transfer catheter. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Zahra sadat Khonsarian
No.13, Nahid Ave, Vafamanesh Ave., Heravi Sq
Tehran Iran (Islamic Republic of) 1668756738 +98 21 2296 7790 hsn.khosropour@gmail.com Tehran University of Medical Sciences scientific Zahra sadat Khonsarian
No.13, Nahid Ave., Vafamanesh Ave., Heravi Sq
Tehran Iran (Islamic Republic of) 1668756738 +98 21 2296 7790 hsn.khosropour@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Age under 40 years (AMH) above one At least twice the previous ART by transferring at least six grade one embryos Healthy uterine cavity in ultrasound and hysteroscopy (lack of uterine anomaly, endometrial polyp, uterine myoma) Absence of endocrinopathy and autoimmune and thrombophilic diseases Normal karyotype Absence of severe male infertility Absence of moderate or severe endometriosis Absence of a specific cause for implantation in previous ARTs Absence of hydrosalpenx no limit 40 years Female Age over 40 years (AMH) below one Abnormal uterine cavities on ultrasound and hysteroscopy (with uterine anomalies, endometrial polyps, uterine myomas) Endocrinopathy and autoimmune and thrombophilic diseases Abnormal karyotype Severe male infertility Existence of a specific cause of non-implantation in previous ARTs Existence of hydrosalpinx Severe or moderate endometriosis Placebo Treatment - Drugs Control group: In the control group, on days 9 and 12, normal intrauterine injection of 600µL sterile saline (5 mg / ml) is performed with a fetal transfer catheter. Intervention group: In patients in the 9 and 12 days of intramuscular injection of dexamethasone 600µL (5 mg / ml) with a fetal transfer catheter. Pregnancy. Timepoint: According to the random list, patients are divided into intervention and control groups.In both groups, after basic ultrasound on the second day of the cycle, the ART cycle begins, and ovarian stimulation information is recorded for each patient. In patients in the 9 and 12 days of intramuscular injection of dexamethasone 600µL (5mg / ml) with a fetal transfer catheter, the intervention is performed slowly.In patients with the control group, the same normal volume of sterile saline is prescribed.Both groups are followed by transvaginal ultrasound while taking ART.When at least two follicles are seen, 10,000 HCG units are injected and 36 hours later the pancreas is transplanted under vaginal ultrasound. The ultrasound is performed two weeks later and the pregnancy sac is examined. Method of measurement: Pregnancy test(ßHCG). Tehran University of Medical Sciences Approved 2019-05-13 Ethics Committee in Research, School of Medicine, Tehran University of Medical Sciences headquarters of Tehran University of Medical Sciences, Intersection of Keshavarz Boulevard and Quds Street Tehran Tehran Iran (Islamic Republic of)