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IRCT20200501047259N1 IRCT 2020-05-17 Oroumia University of Medical Sciences IVIG and COVID19 IVIG(intravenous immunoglobulin) Intravenous immunoglubolin (IVIG) effect on improvement of severe pulmonary damage in COVID 19 disease 2020-05-09 anticipated 40 Complete https://irct.ir/trial/47609 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Single, Purpose: Treatment, Randomization description: computer- generated random number table, Blinding description: randomization of patients will be done by computer- generated random number table and the pharmacist of center only will have knowledge of the randomization code. neither the patients nor the physicians nor those responsible for data analysis were aware of the types of treatment allocated. vials of IVIG and placebo will be in the same shape only code on them different. 3 COVID19. Immune Globulin intravenous (human) flebogamma 5% DIF GRIFOLS will be used, each vial has 5 gram IVIG and patient will receive 4 vial every day for 3 days. Yes - There is a plan to make this available What will be shared: SPSS file When: 6 months after publication To whom: researchers of valid institutes Conditions: for furthur evaluation and meta analysis Where to obtain: Urmia University of medical sciences How to obtain: Requests should be sent by email to Urmia University of Medical Sciences Comments:
public Naser Gharebaghi
Kashani street
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3344 4593 hajizadh.reza@gmail.com Oroumia University of Medical Sciences scientific Reza Hajizadeh
kashani street talegani hospital
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3344 4593 hajizadh.reza@gmail.com Oroumia University of Medical Sciences Iran (Islamic Republic of) stablished COVID 19 in PCR test age more than 18 no response to at least one antiviral and chloroquine drugs more than 30% involvement in chest computed tomography 18 years 100 years Both pregnant women coagulopathies previous hypersensitivity to IVIG left ventricular ejection fraction less than 35% previous lung fibrosis or lung surgery LUNG SARCOIDOSIS OR TUBERCULOSIS COVID19 COVID19 Treatment - Drugs Immune Globulin intravenous (human) flebogamma 5% DIF GRIFOLS will be used, each vial has 5 gram IVIG and patient will receive 4 vial every day for 3 days Increasing of patient's O2 saturation above 90%, improvement of lung involvement in lung CT scan. Timepoint: before discharge. Method of measurement: percentile. Oroumia University of Medical Sciences Approved 2020-04-08 Ethics committee of Urmia University of Medical Sciences Kashani street Urmia West Azarbaijan Iran (Islamic Republic of)