IRCT20080901001165N52 IRCT 2020-05-05 Bagheiat-allah University of Medical Sciences Investigating the efficacy of high dose of glucocorticoid in patients with moderate to severe pneumonia related to COVID-19 Investigating the efficacy of high dose of glucocorticoid in patients with moderate to severe pneumonia related to COVID-19 2020-04-20 anticipated 50 Complete https://irct.ir/trial/47641 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block Randomization method is used to randomized the patients. In this method, the number of people assigned to each group is usually almost equal. Blocks are formed based on the considered variables and within each block, half of the people are involved and half are considered as witnesses. The main goal in this method is to balance the number of participants in each group. 3 COVID-19. Intervention 1: Intervention group: At Day 1: Amp. Methylprednisolone 500mg IV infusion over 1 hour. At Day 2 and 3, Amp. Methylprednisolone 250mg IV infusion over 1 hour. At Day 4 and 5, Amp. Methylprednisolone100mg IV infusion over 1 hour. Then, Tab. Prednisolone 25mg, per oral, daily, until the day of discharge, then Tab. Prednisolone will gradually taper off over during 1 month. All patients will receive routine treatment according to the latest national guideline. Intervention 2: Control group: Includes patients who will not receive high-dose of glucocorticoids during hospitalization. All patients will receive routine treatment according to the latest national guideline. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The release schedule is not clear yet.