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IRCT20200505047304N1 IRCT 2020-10-05 Ahvaz University of Medical Sciences Effect of Metoclopramide on Kidney Stone Comparison of the analgesic effect of intravenous metoclopramide and morphine in the treatment of acute renal colic, A randomized double-blind trial 2020-03-05 anticipated 68 Complete https://irct.ir/trial/47700 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: randomization will be done using the site https://www.sealedenvelope.com/ in two groups A and B in six-digit blocks. This list will be provided to the relevant doctor after printing, Blinding description: Patients and data analyzers will not be informed of the type of drug (A or B) until the end of the study. 3 Renal colic. Intervention 1: control group: In the control group, the severity of pain is first evaluated by Visual Analogue Scale (VAS) criteria and the morphine 0.1 mg / kg is injected with 100cc normal saline and the severity of pain based on VAS is evaluated in zero, 15, 30, 45 and 60 minutes. And if in the 30th minute, the patient's pain criterion is based on VAS is more than 5, morphine is injected again for the patient, and if at the end of 60 minutes, the patient's pain is less than 2, the patient is discharged without additional work. Intervention 2: Using visual analog scale, they are assessed for pain intensity after drug injection (worst possible pain = 10 without pain = 0). Patients receive intravenous metoclopramide intervention at a dose of 10 mg. In the 15th minute, the pain is assessed with VAS, which is considered to be significant for greater than or equal to 2. In the 30th minute from the start of treatment, if the pain is more than 5 with VAS,The patient's pain is controlled with morphine. In the 45th and 60th minutes, the patient's pain is examined according to the VAS criteria. If the patient's pain is less than 2 in the 60th minute based on VAS, the patient is discharged from the emergency room without any additional action. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Taghva Fathi
No 18 , 17 shahrivar hospital
Abadan Iran (Islamic Republic of) 6318911151 +98 61 5335 0950 taghvafathi@gmail.com Ahvaz University of Medical Sciences scientific Reza Ganji
Faculty of pharmacy., Ahvaz Jundishapur University of Medical Science., Esfand Ave., Golestan Blvd
Ahvaz Iran (Islamic Republic of) 6135715794 0098 61 3311 rg.pharm777@gmail.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) All patients aged between 18 and 55 years who have been diagnosed with renal colic 18 years 55 years Both Patients under 18 years and over 55 years old Patients who are allergic to morphine and metoclopramide Patients who do not want to cooperate after the start of research for any reason (e.g. due to drug complications) Patients who do not fill out the consent form Pregnant Women Patients with a Fever over 38 degrees Unstable hemodynamics Heart, kidney, lung or liver defects Use of any sedative up to 24 hours before going to the emergency room. N23 Unspecified renal colic Treatment - Drugs Treatment - Drugs control group: In the control group, the severity of pain is first evaluated by Visual Analogue Scale (VAS) criteria and the morphine 0.1 mg / kg is injected with 100cc normal saline and the severity of pain based on VAS is evaluated in zero, 15, 30, 45 and 60 minutes. And if in the 30th minute, the patient's pain criterion is based on VAS is more than 5, morphine is injected again for the patient, and if at the end of 60 minutes, the patient's pain is less than 2, the patient is discharged without additional work. Using visual analog scale, they are assessed for pain intensity after drug injection (worst possible pain = 10 without pain = 0). Patients receive intravenous metoclopramide intervention at a dose of 10 mg. In the 15th minute, the pain is assessed with VAS, which is considered to be significant for greater than or equal to 2. In the 30th minute from the start of treatment, if the pain is more than 5 with VAS,The patient's pain is controlled with morphine. In the 45th and 60th minutes, the patient's pain is examined according to the VAS criteria. If the patient's pain is less than 2 in the 60th minute based on VAS, the patient is discharged from the emergency room without any additional action. Average pain score on visual analogue scale. Timepoint: Measuring the average pain score at the beginning of the study (before starting the intervention) and 15, 30, 45 and 60 minutes after the intervention begins. Method of measurement: VAS (Visual Analogue Scale). Ahvaz University of Medical Sciences Approved 2020-02-23 Ethics committee of Ahvaz Jundishapur University of Medical Sciences Ahvaz Jundishapur University of Medical Science., Esfand Ave., Golestan Blvd Ahvaz Khouzestan Iran (Islamic Republic of)