IRCT20200510047380N1 IRCT 2020-06-15 Vice-Chancellor For Research and Technology of Guilan University of Medical Sciences Effect of timing of heparin injection on acute STEMI treatment The effect of timing of Heparin injection on the TIMI Flow grade in the STEMI patients undergoing primary PCI 2020-05-21 anticipated 120 Complete https://irct.ir/trial/47992 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Subjects with eligible criteria are randomly assigned into two groups using the random block method with size 4. These patients will be divided into two groups: early heparin administration group in the emergency department, and late heparin administration group in the cath lab unit. Random sequences will be generated using computer. After generating the list, a specific code will be assigned to each person, and will be identified by it during the study. Registration and the sequence of random allocation is done by a third person. The sampling method is consecutive. Sampling is started based on the patients’ gradual referrals to the emergency department and completed documents, and will be continued to reach the required sample size. 3 Acute myocardial infarction with ST elevation. Intervention 1: Intervention group: Patients with STEMI in intervention group whom will receive bolus dose of 90u/kg IV heparin UFH in emergency department. Intervention 2: Control group: bolus 90 u/kg IV heparin as hospital routine and during PCI. Yes - There is a plan to make this available What will be shared: Spss file will include all data about acute MI (onset of chest pain, duration of chest pain, anterior ,lateral, high lateral , extensive anterolateral, inferior, posterior, septal, RV MI) , LVEF during hospitalization, heart rate on the electrocardiogram, systolic and diastolic blood pressure, killip class , treatment group, Early Bolus heparin administration in emergency department and Late bolus heparin in the catch lab, and referring for CABG. Angiographic and angioplastic data including Identifiable culprit vessel, vascular access TIMI FLOW of culprit vessel: , LM،LAD،Diagonal، LCX، OM، RCA، PDA Before and after Primary PCI, HOSPITAL complications ( stent thrombosis, local side effects of angiography including bleeding and hematoma, ventricular tachyarrhythmia (VT,VF) Flail MV, Vntricular septal rupture , free wall rupture , pericardial effusion. Clinical data about LVEF 40 days after STEMI. When: 6 month after the results are published, the access period will be start. To whom: Researchers working in academic and scientific institutions. Conditions: To obtain new results, researchers will be permitted to use further analysis and the data in the future researches. Where to obtain: Healthy Heart Research Center, Dr Heshmat heart hospital, Mosalla Square, Rasht, Guilan, Iran Phone number: 00981333664282 P.O.Box: 41939-55588 Fax: 00981333668718 How to obtain: A written request with sufficient detail should be sent to the postal address.After receiving the request, the scientific correspondence author will be responsive within one week. Comments: