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IRCT20200422047166N1 IRCT 2020-06-10 Esfahan University of Medical Sciences Effect of zinc tablets in the prevention of acute peripheral neuropathy in cancer patients treated with taxanes Comparative study of the effect of 25 mg zinc tablets with placebo on the rate of prevention of acute peripheral neuropathy in cancer patients treated with taxanes 2020-05-25 anticipated 60 Complete https://irct.ir/trial/48078 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The study sample is randomly selected and then randomly assigned to the intervention and control group using individual and pair blocks, Blinding description: Envelopes will be given to patients at random. The patient then delivers the envelope to the drug distributor, where the patient code is recorded. It should be noted that the patient will not be aware of the nature of their medication (medication or placebo) and the physician collecting the study information (internal medicine assistant) will not know the patient's code (the study is two-course). 3 Drug-induced polyneuropathy. Intervention 1: Control group: Patients in the control group receive placebo capsule (25 mg) daily for two hours after lunch for 12 weeks. Intervention 2: Intervention group: Patients in the intervention group receive 25 mg of zinc sulfate capsule (Alhavi Pharma) daily for two hours after lunch for 12 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I will decide until finishing the study
public Ali Haji Gholami
Al-Zahra Hospital, Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) 7346181746 +98 913 369 2567 Alihajigholami@med.mui.ac.ir Esfahan University of Medical Sciences scientific Ali Haji Gholami
Al-Zahra Hospital, Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) 7346181746 +98 913 369 2567 Alihajigholami@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Cancer confirmed by biopsy and candidate for chemotherapy containing taxan Be able to give informed consent. The patient's performance status should be such that he or she can describe the condition. no limit no limit Both They have diabetes, neurological disorders or neuropathy G62.0 Drug-induced polyneuropathy Placebo Treatment - Drugs Control group: Patients in the control group receive placebo capsule (25 mg) daily for two hours after lunch for 12 weeks. Intervention group: Patients in the intervention group receive 25 mg of zinc sulfate capsule (Alhavi Pharma) daily for two hours after lunch for 12 weeks. Severity of neuropathy. Timepoint: Every 3 weeks for 3 months. Method of measurement: Criteria for side effects table. Acute neuropathy. Timepoint: Every 3 weeks for 3 months. Method of measurement: Examination. Esfahan University of Medical Sciences Approved 2020-02-29 Ethics Committee of Isfahan University of Medical Sciences Isfahn University of Medical Sciences, Hezar Jarib st, Isfahan Isfahan Isfehan Iran (Islamic Republic of)