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IRCT20130304012695N2 IRCT 2020-05-26 Tehran University of Medical Sciences Analgesic effect of combining Midazolam, Morphine and Diphenhydramine for acute postoperative pain management, A comparative study Analgesic effect of combining Midazolam, Morphine and Diphenhydramine for acute postoperative pain management, A comparative study 2019-01-21 anticipated 66 Complete https://irct.ir/trial/48238 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The sampling is done by easy burst method and according to patient referral to recovery room. Randomization method is balanced block randomization and will be done by Randlist software, Blinding description: The person who makes the medicine add a code to every single medicine . The person who injects the drug does not know the code. The patient is not aware of the type of injectable medication. The researcher is not aware of the type of drug during the study. 3 postoperative pain. Intervention 1: Intervention group: Morphine, Midazolam, In this group, in a syringe of 10 cc, 10 mg of morphine, 100 mg of diphenhydramine and 10 mg of midazolam,prepared then increase the volume to 10 cc with distilled water.In patients who have pain and want to take analgesia, we inject one cc of this medicine mixture. Two minutes after the injection, if the pain is not controlled, we take another cc of this mixture. we record the number of injections and reduce the severity of the pain and the duration of the pain reduction per minute. Intervention 2: Control group: Morphine, ketamine, Diphenhydramine.In this group, in a syringe of 10 cc, 10 mg of morphine, 100 mg of diphenhydramine and 10 mg of ketamine,prepared then increase the volume to 10 cc with distilled water.In patients who have pain and want to take analgesia, we inject one cc of this medicine mixture. Two minutes after the injection, if the pain is not controlled, we take another cc of this mixture. we record the number of injections and reduce the severity of the pain and the duration of the pain reduction per minute. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is unknown at this time what will be done
public Mohammadreza Khajavi
Central building of Tehran University of Medical sciences, Ghods st., Keshavarz blv.
Tehran Iran (Islamic Republic of) 1136746911 +98 21 6312 1220 khajavim@tums.ac.ir Tehran University of Medical Sciences scientific Mohammadreza Khajavi
Central building of Tehran University of Medical sciences, Ghods st., Keshavarz blv.
Tehran Iran (Islamic Republic of) 1136746911 +98 21 6312 1220 khajavim@tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Patients are extubated after surgery and recover. In recovery, patients were evaluated based on VAS or Richmond criteria, and if they had a VAS> 4 score or Richmond +2 and above, they entered the study and were randomly assigned to one of the two groups. 20 years 65 years Both opioids addiction, underlying ischemic cardiac diseases, renal function and liver function diseases, history of allergic reaction to any of the medications used, and use of any antiemetic and antipsychotic medications, PONV and glaucoma. S66.0 Injury of long flexor muscle, fascia and tendon of thumb at wrist and hand level Treatment - Drugs Treatment - Drugs Intervention group: Morphine, Midazolam, In this group, in a syringe of 10 cc, 10 mg of morphine, 100 mg of diphenhydramine and 10 mg of midazolam,prepared then increase the volume to 10 cc with distilled water.In patients who have pain and want to take analgesia, we inject one cc of this medicine mixture. Two minutes after the injection, if the pain is not controlled, we take another cc of this mixture. we record the number of injections and reduce the severity of the pain and the duration of the pain reduction per minute. Control group: Morphine, ketamine, Diphenhydramine.In this group, in a syringe of 10 cc, 10 mg of morphine, 100 mg of diphenhydramine and 10 mg of ketamine,prepared then increase the volume to 10 cc with distilled water.In patients who have pain and want to take analgesia, we inject one cc of this medicine mixture. Two minutes after the injection, if the pain is not controlled, we take another cc of this mixture. we record the number of injections and reduce the severity of the pain and the duration of the pain reduction per minute. The effect of the drug combination of midazolam, diphenhydramine and morphine on pain relief. Timepoint: In 5, 10, 15, 30 minutes after the operation, the severity pain was measured. Method of measurement: visual analog scal. Patients' agitation evaluation. Timepoint: In 5, 10, 15 and 30 minutes after surgery. Method of measurement: richmond agitation scale. Tehran University of Medical Sciences Approved 2018-11-19 Ethics committee of ،tehran University of Medical Sciences sina hospital, imam khomeini st. tehran Tehran Iran (Islamic Republic of)