]>
IRCT20110726007117N11 IRCT 2020-07-05 Mashhad University of Medical Sciences Effect of vitamin D supplementation in novel corona virus 2019 Effect of vitamin D supplementation in diagnosed cases of 2019 Novel Coronavirus; a randomized clinical trial 2020-06-21 anticipated 140 Complete https://irct.ir/trial/48287 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The eligible participants will undergo individual block randomization according to sex status with the use of block size of three. For this randomization, we will use solid blurred envelops containing A or B or C labels, Blinding description: Blinding will be perfomed in two levels of patients and investigators (double blind). 3 Covid-19 disease. Intervention 1: Intervention group: 50000 International Unit (IU) pearl vitamin D as single dose, made in ZAHRAVI manufacture and then 10000 IU vitamin D syrup , 30 days, with lunch, Made in the department of Pharmacology Mashhad University of Medical Sciences. Intervention 2: Control group: 1000 International Unit (IU) syrup vitamin D daily, 30 days, with lunch, Made in the department of Pharmacology Mashhad University of Medical Sciences. No - There is not a plan to make this available Justification or reason for not sharing IPD is All patients' identical information will be confidential and were not published anywhere.
public Doctor Majid Ghayour Mobarhan
Faculty of Medicine, Mashhad University of Medical Sciences Campus, Azadi Square
Mashhad Iran (Islamic Republic of) 9177948546 +98 51 3800 2420 Ghayourm@mums.ac.ir Mashhad University of Medical Sciences scientific Doctor Majid Ghayour Mobarhan
Faculty of Medicine, Mashhad University of Medical Sciences Campus, Azadi Square
Mashhad Iran (Islamic Republic of) 9177948546 +98 51 3800 2420 Ghayourm@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Age 30- 60 years old Serum Vitamin D level lower than 30 nanograms per milliliter Cases who diagnosed as novel coronavirus 2019 infection by clinical features (sore throat, dry cough, dyspnea), laboratory findings (positive C- Reactive protein, lymphocyte<1100 per mililiter), or radiological findings (lung patchy infiltrations in chest X-ray or CT scan) 30 years 60 years Both Serum Vitamin D level upper than 30 nanograms per milliliter Use of medications that interfere with vitamin D metabolism History of hypercalcemia, kidney disorders, cirrhosis U07.1 Use this code when COVID-19 has been confirmed by laboratory testing irrespective of severity of clinical signs or symptoms. Use additional code, if desired, to identify pneumonia or other manifestations. Treatment - Drugs Treatment - Drugs Intervention group: 50000 International Unit (IU) pearl vitamin D as single dose, made in ZAHRAVI manufacture and then 10000 IU vitamin D syrup , 30 days, with lunch, Made in the department of Pharmacology Mashhad University of Medical Sciences Control group: 1000 International Unit (IU) syrup vitamin D daily, 30 days, with lunch, Made in the department of Pharmacology Mashhad University of Medical Sciences C-Reactive Protein level. Timepoint: Measurement of C-Reactive Protein level before starting intervention and 30 days after starting the intake of vitamin D supplementation. Method of measurement: enzyme-linked immunosorbent assay kit. Erythrocyte Sedimentation Rate level. Timepoint: Measurement of Erythrocyte sedimentation level before starting intervention and 30 days after starting the intake of vitamin D supplementation. Method of measurement: Westergren method. Neutrophil to lymphocyte ratio level. Timepoint: Measurement of neutrophil to lymphocyte ratio level before starting intervention and 30 days after starting the intake of vitamin D supplementation. Method of measurement: microscopic count. Serum vitamin D level. Timepoint: Measurement of serum vitamin D level before starting intervention and 30 days after starting the intake of vitamin D supplementation. Method of measurement: Enzyme-linked immunosorbent assay. Low Density Lipoprotein Level. Timepoint: Measurement of Low Density Lipoprotein level before starting intervention and 30 days after starting the intake of vitamin D supplementation. Method of measurement: Direct detergent method. High Density Lipoprotein Level. Timepoint: Measurement of High Density Lipoprotein level before starting intervention and 30 days after starting the intake of vitamin D supplementation. Method of measurement: Direct detergent method. Total cholesterol level. Timepoint: Measurement of total cholesterol level before starting intervention and 30 days after starting the intake of vitamin D supplementation. Method of measurement: Direct detergent method. Triglyceride level. Timepoint: Measurement of tryglyserid level before starting intervention and 30 days after starting the intake of vitamin D supplementation. Method of measurement: Direct detergent method. Fasting Blood Glucose level. Timepoint: Measurement of Fasting Blood Glucose level before starting intervention and 30 days after starting the intake of vitamin D supplementation. Method of measurement: Enzymatic colorimetric method. Mashhad University of Medical Sciences Approved 2020-05-09 Ethics committee of Mashhad University of Medical Sciences Faculty of Medicine, Mashhad University of Medical Sciences Campus, Azadi Square Mashhad Razavi Khorasan Iran (Islamic Republic of)