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IRCT20130311012782N47 IRCT 2020-06-10 Esfahan University of Medical Sciences Comparison effect of oral dydrogesterone with vaginalprogesterone in the treatment of infertility by intrauterine sperm injection compression of oral Dydrogestrone with vaginal Progestron in IUI successfull in patient with unexplained infertility 2020-08-22 anticipated 210 Complete https://irct.ir/trial/48301 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization of patients in two groups is done using Random Allocation Software. In this software, first the total volume of the sample enters the software and in the next step, the number of groups is specified. Software output includes a list of numbers from 1 to 210 that are randomly distributed in groups Aو B and C. Patients are divided into three groups according to the time list, according to the time list, so that the sample size reaches the required number, Blinding description: Patients are unaware of the type of medication they are taking. Diderotestron is marketed as the main drug and coded on the main drug and placebo, and is given to patients for use. The outcome of treatment is also checked by a gynecologist who is unaware of the type of medication being taken. 3 unexplained infertility. Intervention 1: Intervention Group 1: Infertile women treated with intrauterine sperm injection with oral administration of 10 mg oral tablets of Dydrogesterone, one tablet per night for 16 days. Intervention 2: Intervention Group 2: Infertile women treated with intrauterine sperm injection with progesterone vaginal suppositories, 400 mg, one suppository per night for 16 days. Intervention 3: Control group: Infertile women treated with intrauterine sperm injection with oral administration of didrogesterone placebo, one pill a night for 16 days. No - There is not a plan to make this available Justification or reason for not sharing IPD is The plan belongs to the government agency and it is not possible to publish its information.
public Hatav Ghasemi Tehrani
Shahid Beheshti hospital, Motahari street, Isfahan
Isfahan Iran (Islamic Republic of) 8434193474 +98 31 3668 5555 tehrani@med.mui.ac.ir Esfahan University of Medical Sciences scientific Elham Naghshineh
Shahid Beheshti hospital, Motahari street, Isfahan
Isfahan Iran (Islamic Republic of) 8434193474 +98 31 3668 5555 naghshineh@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Visiting women with unexplained infertility Indications for treatment of intrauterine sperm injection Patient's consent to participate in the study Maximum 45 years old no limit 45 years Female Do other infertility treatments at the same time N97.9 unexplained infertility Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention Group 1: Infertile women treated with intrauterine sperm injection with oral administration of 10 mg oral tablets of Dydrogesterone, one tablet per night for 16 days Intervention Group 2: Infertile women treated with intrauterine sperm injection with progesterone vaginal suppositories, 400 mg, one suppository per night for 16 days Control group: Infertile women treated with intrauterine sperm injection with oral administration of didrogesterone placebo, one pill a night for 16 days Fertility success. Timepoint: 16 days after treatment. Method of measurement: Measurement of beta HCG. Esfahan University of Medical Sciences Approved 2019-03-12 Ethics committee of Isfahan University of Medical Sciences Research faculty, Isfahan University of Medicla Sciences, Hezarjerib street, Isfahan Isfahan Isfehan Iran (Islamic Republic of)