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IRCT20100119003106N40 IRCT 2020-07-10 Islamic Azad University Evaluation of clarithromycin on IL-6 serum level in patients with multiple sclerosis Evaluation of clarithromycin on IL-6 serum level in patients with multiple sclerosis: A randomized, double-Blind, crossover, placebo-controlled pilot study 2020-05-21 anticipated 28 Complete https://irct.ir/trial/48412 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment, Randomization description: 28 envelopes are prepared with 14 active and 14 placebo cards and shuffled. Patients are allocated the next study number (1–28) in sequence after opening the sealed envelopes to either drug or placebo group, Blinding description: The patients, physicians, researcher and data collector (student) don’t know about who was receving the actual drug and who receving a placebo. The informed consent was obtained from patients and they were informed that they could leave the trial at any time. The coding of the medicine boxes was done by a third party who was not involved in the study and at the end of the study, decryption took place. 2-3 Multiple sclerosis. MS patients were randomly assigned to receive either clarithromycin (500mg) or placebo tablets twice daily for 14 days. Subsequently, after a 1-month washout, they were crossed over to the other group during the course of the trial.. Yes - There is a plan to make this available What will be shared: All the data potentially can be shared after being unidentifiable. When: Just after the article's publication. To whom: For all investigators. Conditions: No more information. Where to obtain: Applicants can refer to the Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Dr.Hashemian or contact the researcher by sending email to ghazalamiri1995@gmail.com or calling 09120680122. How to obtain: Applicants can apply for research information by visiting the department or by contacting the e-mail address and telephone number as well as providing information on academic studies and the purpose of requesting the information. Applicants must commit themselves to mention the source. If the request is sent six months after the publication of the research information, the researcher will send the data to the requesting party by email within a week. Comments: There is no more information.
public Ghazal Amiri
No 99, Yasaman Alley, Yakhchal St, Shariati Av
Tehran Iran (Islamic Republic of) 1941933111 +98 21 2264 0051 ghazalamiri1995@gmail.com Islamic Azad University scientific Dr. Farshad Hashemian
No 99, Yasaman Alley, Yakhchal St, Shariati Av
Tehran Iran (Islamic Republic of) 193956466 +98 21 2264 0599 hashemian.f@iaups.ac.ir Islamic Azad University Iran (Islamic Republic of) Age of 20 t 60 years Confirmed diagnosis of primary progressive progressive MS No medical history of allergy to clarithromycin 20 years 60 years Both Pregnancy and lactation Serious underlying medical conditions (e.g malignancy, renal and hepatic failure) Known hypersensitivity to clarithromycin and excipients Significant signs of depression G35 Multiple sclerosis N/A MS patients were randomly assigned to receive either clarithromycin (500mg) or placebo tablets twice daily for 14 days. Subsequently, after a 1-month washout, they were crossed over to the other group during the course of the trial. Interleukin 6. Timepoint: Before intervention, week 2, 6 and 8 after intervention. Method of measurement: ELISA Kit. Quality of life. Timepoint: Before intervention, week 2, 6 and 8 after intervention. Method of measurement: The quality of life questionnaire. Islamic Azad University Approved 2019-11-20 Ethics committee of Islamic Azad University of Tehran Medical Sciences No 99, Yakhchal street, Gholhak, Dr Shariati street Tehran Tehran Iran (Islamic Republic of)