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IRCT20160602028225N2 IRCT 2020-05-29 Iran University of Medical Sciences Effect of intravenous paracetamol on pain during and after prostate surgery. Comparison of the effectiveness of intravenous paracetamol before surgery on the dose of opioid during and after radical prostatectomy. 2020-05-20 anticipated 36 Complete https://irct.ir/trial/48436 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, we use the block randomization method to create equal groups. To randomize the two treatment methods, we create 4 blocks in six different states, then select a number using the table of numbers, and determine the study groups by matching the numbers with the blocks. 1. TTCC 2. TCTC 3. TCCT 4. CCTT 5. CTCT 6. CTTC For example, if the first digit of our number is 1 to 6, select a block and the division is done, but if, for example, our number is 94071, the digit 9 is not valid and we select the next digit. Here, based on the block, we divide 4 people into groups, Blinding description: The researcher and the person analyzing the study information are unaware of the study groups and are identified as groups A and B. 3 Prostate Cancer. Intervention 1: Intervention group: In the first group, intravenous paracetamol will be injected at a rate of one gram, and then one gram will be given one hour after the anesthesia injection.  During surgery, the amount of injectable fentanyl (500 micrograms per 10 cc ampoule made by Caspian Pharmaceutical Company) is based on the patient's weight every hour during the operation, as well as the injected petidine (50 mg per cc made by Caspian Pharmaceutical Company) based on VAS will be determined and recorded for the patient. Also, the severity of pain after surgery will be determined and recorded at recovery times, 2, 8, and 24 hours after recovery. Also, the prescribed dose of opioids will be determined during the 24 hours after the operation at the time of hospitalization, and finally the total length of hospital stay will be determined. Intervention 2: Control group: In the second group, the placebo will be injected at a rate of one gram, and then one gram will be given an hour after the anesthesia injection.During surgery, the amount of injectable fentanyl (500 micrograms per 10 cc ampoule made by Caspian Pharmaceutical Company) is based on the patient's weight every hour during the operation, as well as the injected petidine (50 mg per cc made by Caspian Pharmaceutical Company) based on VAS will be determined and recorded for the patient. Also, the severity of pain after surgery will be determined and recorded at recovery times, 2, 8, and 24 hours after recovery. Also, the prescribed dose of opioids will be determined within 24 hours after the operation at the time of hospitalization, and finally the total length of hospital stay will be determined. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Reza Mohaghegh
Iran University of Medical Sciences., Hemmat Highway., Next to Milad Tower., Tehran Town
Tehran Iran (Islamic Republic of) 1433933111 +98 21 8864 4411 mohaghegh_mr@yahoo.com Iran University of Medical Sciences scientific Reza Mohaghegh
Iran University of Medical Sciences., Hemmat Highway., Next to Milad Tower., Tehran Town
Tehran Iran (Islamic Republic of) 1433933111 +98 21 8864 4411 mohaghegh_mr@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) Age over 40 years 40 years no limit Male History of chronic drug use Liver disorder Kidney disorder C61 Malignant neoplasm of prostate Treatment - Drugs Treatment - Drugs Intervention group: In the first group, intravenous paracetamol will be injected at a rate of one gram, and then one gram will be given one hour after the anesthesia injection.  During surgery, the amount of injectable fentanyl (500 micrograms per 10 cc ampoule made by Caspian Pharmaceutical Company) is based on the patient's weight every hour during the operation, as well as the injected petidine (50 mg per cc made by Caspian Pharmaceutical Company) based on VAS will be determined and recorded for the patient. Also, the severity of pain after surgery will be determined and recorded at recovery times, 2, 8, and 24 hours after recovery. Also, the prescribed dose of opioids will be determined during the 24 hours after the operation at the time of hospitalization, and finally the total length of hospital stay will be determined. Control group: In the second group, the placebo will be injected at a rate of one gram, and then one gram will be given an hour after the anesthesia injection.During surgery, the amount of injectable fentanyl (500 micrograms per 10 cc ampoule made by Caspian Pharmaceutical Company) is based on the patient's weight every hour during the operation, as well as the injected petidine (50 mg per cc made by Caspian Pharmaceutical Company) based on VAS will be determined and recorded for the patient. Also, the severity of pain after surgery will be determined and recorded at recovery times, 2, 8, and 24 hours after recovery. Also, the prescribed dose of opioids will be determined within 24 hours after the operation at the time of hospitalization, and finally the total length of hospital stay will be determined. Severity of pain. Timepoint: Before and after surgery. Method of measurement: Visual analogue scale. Doses of opioids. Timepoint: During and after surgery. Method of measurement: File registration. Hospital length. Timepoint: After surgery. Method of measurement: Hospital follow-up. Iran University of Medical Sciences Approved 2020-05-16 Ethics committee of Iran University of Medical Sciences Iran University of Medical Sciences., Hemmat Highway., Next to Milad Tower., Tehran Town Tehran Tehran Iran (Islamic Republic of)