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IRCT20181030041503N3 IRCT 2020-06-25 Mashhad University of Medical Sciences Comparison of embryo transfer in two different protocol Comparison of the consequences of freezing embryo transfer in infertile women with tamoxifen and recombinant gonadotropin group with GNRH agonist group and estradiol valerate 2019-05-22 anticipated 96 Complete https://irct.ir/trial/48457 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: -Simple randomization. -In this randomized clinical trial involving 192 women (18-42 years), two groups were randomly assigned. -Method used to generate random allocation sequence by mentioning the name of the software or site used: Computer random assignment list produced with PASS software. -We have no way to hide Allocation Concealment, Blinding description: The analyst will be unaware of the intervention and control groups. It is not possible for patients to be blind because the type of medication prescribed to patients (injectable and oral) varies in two groups. N/A infertility. Intervention 1: The intervention group included 96 patients who were given 20 mg of tamoxifen twice daily for the third day of the cycle for five days, and HMG was given at 150 mg daily on days 6 and 8. Subsequent patient evaluation is performed on days 9 to 10 of the cycle with transvaginal ultrasound to measure the diameter of the follicle and the thickness of the endometrium. And if the thickness of the endometrium is 8 mm and the diameter of the dominant follicle is 18 mm, HCG10000 IU is injected to induce ovulation. 36 hours after HCG injection, the progesterone utrogestan (Besrogestan, Besins, Brussels, Belgium) 200 mg vaginal 200 mg three times daily or 100 mg endometriosis three times a day. Progesterone continues until the pregnancy test results. Endometrial thickness per day HCG Is checked. Intervention 2: Control group: In the control group, the OCP receives for 21 days, and on the 21st day of the cycle, one-third of the 3.75 decapeptil is prescribed. On the second day of the next cycle, estradiol is started at a dose of 4 mg and after three days it is converted to 6 mg. On the ninth day, ultrasound is performed in terms of endometrial thickness and increases to a maximum of 8 mg per day as needed. 100 ml endometrium is started three times a day. Progesterone is given for 5 days for blastocyst. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I'm looking into the matter
public Maliheh Mahmoudinia
Milad Fertility clinic, East Razi Streat, Dah e Day Square.
Mashhad Iran (Islamic Republic of) 9178631973 +98 51 3853 4021 MahmoudiniamM@mums.ac.ir Mashhad University of Medical Sciences scientific Nayyereh Khadem
Emam Reza Hospital, Ebne Sina Streat
Mashhad Iran (Islamic Republic of) 9178631973 +98 51 3801 2607 khademn@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Infertile women (18-42 years old) who go to Milad Infertility Center for transfer freezing embryo with a history of two or more failed embryo transfer. Couples who are not severely infertile or TESE candidate (Testicular Sperm Extrection) . may not have severe grade 3 and 4 endometriosis. may not have fibroids> 4 cm. may not be candidates for fresh embryo transfer. and may not have primary and secondary amenorrhea. 18 years 42 years Female Failure to remove the fetus from the freezer, , necrotic embryo patient dissatisfaction during treatment to continue the study N98.3 Complications of attempted introduction of embryo in embryo transfer Treatment - Drugs Treatment - Drugs The intervention group included 96 patients who were given 20 mg of tamoxifen twice daily for the third day of the cycle for five days, and HMG was given at 150 mg daily on days 6 and 8. Subsequent patient evaluation is performed on days 9 to 10 of the cycle with transvaginal ultrasound to measure the diameter of the follicle and the thickness of the endometrium. And if the thickness of the endometrium is 8 mm and the diameter of the dominant follicle is 18 mm, HCG10000 IU is injected to induce ovulation. 36 hours after HCG injection, the progesterone utrogestan (Besrogestan, Besins, Brussels, Belgium) 200 mg vaginal 200 mg three times daily or 100 mg endometriosis three times a day. Progesterone continues until the pregnancy test results. Endometrial thickness per day HCG Is checked. Control group: In the control group, the OCP receives for 21 days, and on the 21st day of the cycle, one-third of the 3.75 decapeptil is prescribed. On the second day of the next cycle, estradiol is started at a dose of 4 mg and after three days it is converted to 6 mg. On the ninth day, ultrasound is performed in terms of endometrial thickness and increases to a maximum of 8 mg per day as needed. 100 ml endometrium is started three times a day. Progesterone is given for 5 days for blastocyst. Chemical pregnancy rate. Timepoint: 2 week after embryo transfer. Method of measurement: BHCG. The rate of clinical pregnancy. Timepoint: 6 weeks after embryo transfer. Method of measurement: Sonography. Ongoing pregnancy. Timepoint: Continue pregnancy for up to 12 weeks. Method of measurement: Transvaginal ultrasound. Mashhad University of Medical Sciences Approved 2019-01-29 Mashhad university of medical sciences Ethics committee Vice chancellor of Research, Mashhad university of Medical Sciences, Mashhad University of Medical Sciences ,University Avenue.Mashhad Mashhad Razavi Khorasan Iran (Islamic Republic of)