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IRCT20200427047219N2 IRCT 2020-05-31 Zanjan University of Medical Sciences Evaluation of the effects of Cydonia Oblonga Mill. fruit syrup on reduction of Biochemical complications induced by Herceptin in patients with breast cancer Evaluation of the effects of Cydonia Oblonga Mill. fruit syrup on reduction of Biochemical complications induced by Trastuzumab (Herceptin) in patients with breast cancer: A randomized double blind clinical trial study 2020-09-05 anticipated 60 Complete https://irct.ir/trial/48458 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: This study will be a two-course clinical trial. The study population will be randomly selected from patients with HER2-positive breast cancer who go to clinics and hospitals affiliated with Zanjan University of Medical Sciences. Diagnosis will be made by an oncologist using blood tests, ultrasound, and, if necessary, additional procedures, Blinding description: The container containing the extract and placebo will be uniform in appearance, and patients, as well as researchers, will be blind to the content of the contents of the bottles during the study and whether participants will receive the extract or placebo. For the preparation of placebo syrup, the base of the main syrup is used without extract, and for the uniformity of the shape, taste and smell of both types and types of syrup, apple essential oil and food coloring are allowed in very low doses. These syrups are made of sugar and according to the usp. Containers containing placebo and extract are coded by a third party and delivered to patients. 1-2 Breast cancer. Intervention group: Patients with breast cancer receiving quince syrup. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Mohammad Reza
Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan Univrsity of Medical Sciences,
Zanjan Iran (Islamic Republic of) 45139-56184 +98 24 3347 3638 eskandarimr@zums.ac.ir Zanjan University of Medical Sciences scientific Mohammad Reza Eskandari
Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences
Zanjan Iran (Islamic Republic of) 45139-56184 +98 24 3347 3638 eskandarimr@zums.ac.ir Zanjan University of Medical Sciences Iran (Islamic Republic of) The desire to participate in the study Breast cancer in the early stages of the disease HER2 positive Women over 18 years Life expectancy more than 3 months (with a doctor's diagnosis) A person should at least be able to walk and do their own thing (WHO performance status 0-2) 18 years no limit Female Suffering from other cancers Thyroid or kidney disorders Get other vitamin or mineral supplements Patients with a body mass index less than 18.5 Lack of willingness to continue participating in the project for any reason Prevention Intervention group: Patients with breast cancer receiving quince syrup Biochemical factors including: ALP,GGT,ALT, AST. Timepoint: At the beginning of the experiment and 3 months after the intervention. Method of measurement: Laboratory kits. Biochemical factors. Timepoint: Start of study (before the start of the intervention) and 3 months later. Method of measurement: Laboratory kits. Zanjan University of Medical Sciences Approved 2020-01-11 Committee of Animal Experimentation of Zanjan University of Medical Sciences, Zanjan Azadi Blvd., Central Headquarters of Zanjan University of Medical Sciences, Second Building, Third Floor, Deputy of Research and Technology Zanjan Zanjan Iran (Islamic Republic of)