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IRCT20161014030294N4 IRCT 2020-09-09 Arak University of Medical Sciences Comparison of the effect of botanical extract mouthwashes of meswak/aloe vera and chlorhexidine on prevention of ventilator-associated pneumonia Comparison of the effect of botanical extract mouthwashes of meswak/aloe vera and chlorhexidine on prevention of ventilator-associated pneumonia in ventilated patient 2020-06-20 anticipated 70 Complete https://irct.ir/trial/48564 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Sampling is done purposefully. We perform permutation block randomization method with statistical software. We considered four blocks for two mouthwashes. The possibility of predicting the type of treatment for the researcher is reduced, Blinding description: Patients are divided into two groups in the form of permutation blocks. Patients and caregivers and nurses responsible for collecting data are unaware of the type of mouthwash used. Mouthwashes are used in the same container and labeled A and B so that they are not identifiable in terms of the type of mouthwash.Patients do not notice the difference in the taste of mouthwash due to intubation and anesthesia. 3 Ventilator-associated pneumonia. Intervention 1: Intervention group: Mouthwash containing toothbrush wood extract / Aloe vera produced by Barij Essential Oil Company is used. 5 ml of mouthwash is poured into different parts of the mouth using a syringe and immediately sucked. This operation is performed every 8 hours by the nurse for 14 days. The lung secretion culture test is performed on the third, seventh and fourteenth day. Intervention 2: Control group: Mouthwash containing 0.2% chlorhexidine is used. 5 ml of mouthwash is poured into different parts of the mouth using a syringe and immediately sucked. This operation is performed every 8 hours by the nurse for 14 days. The lung secretion culture test is performed on the third, seventh and fourteenth day. Yes - There is a plan to make this available What will be shared: All potential data can be shared after people have not been identified When: Start the access period 2 months after printing the results To whom: Researchers working in academic and scientific institutions Conditions: Use documentation by citing the source Where to obtain: Mansoreh Karimi Kia Arak University of Medical Sciences Phone 09181600717 Email karimikia93@gmail.com How to obtain: After receiving the request by phone or email, the data will be sent within 2 weeks. Comments:
public Mansoreh Karimi Kia
A'lam-Al-Hoda Street, Shahid Shiroodi Street, Arak, Markazi Province, Iran
Arak Iran (Islamic Republic of) ٣٨١٩٦٩٣٣٤٥ +98 86 3313 6055 karimikia93@gmail.com Arak University of Medical Sciences scientific Behnam Mahmoudieh
A'lam-Al-Hoda Street, Shahid Shiroodi Street, Arak, Markazi Province, Iran
Arak Iran (Islamic Republic of) 3819693345 +98 86 3313 6055 Behnammahmoudye@yahoo.com Arak University of Medical Sciences Iran (Islamic Republic of) Existence of endotracheal tube through the mouth Age 16 to 65 years Mechanical ventilation for at least 72 hours Absence of lung infection based on the clinical score of the modified lung infection Lack of sensitivity to plant compounds Absence of sepsis Absence of pulmonary thromboembolism Absence of atelectasis Absence of inflammatory diseases of the gastrointestinal tract Absence of severe liver and bile duct diseases 16 years 65 years Both Transfer the patient from the ICU or die before completing the study Reluctance of the patient's companions to continue the study Observe the side effects of using mouthwash such as hives, itching and skin rashes Sudden changes in the patient's clinical condition or respiratory pattern occur Existence of defects in the patient's immune system Prevention Prevention Intervention group: Mouthwash containing toothbrush wood extract / Aloe vera produced by Barij Essential Oil Company is used. 5 ml of mouthwash is poured into different parts of the mouth using a syringe and immediately sucked. This operation is performed every 8 hours by the nurse for 14 days. The lung secretion culture test is performed on the third, seventh and fourteenth day. Control group: Mouthwash containing 0.2% chlorhexidine is used. 5 ml of mouthwash is poured into different parts of the mouth using a syringe and immediately sucked. This operation is performed every 8 hours by the nurse for 14 days. The lung secretion culture test is performed on the third, seventh and fourteenth day. The rate of ventilator-induced pneumonia. Timepoint: 72 hours and 7 days after the intervention and when the patient is extubated. Method of measurement: Microbiological tests of lung secretions. Arak University of Medical Sciences Approved 2019-06-08 Ethics Committee of Arak University of Medical Sciences A'lam-Al-Hoda Street, Shahid Shiroodi Street, Arak, Markazi Province, Iran Arak Markazi Iran (Islamic Republic of)