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IRCT20200603047645N1 IRCT 2020-06-21 Arak University of Medical Sciences Effect of epinephrine on coroner bypass graft Comparison of the effect of local epinephrine and norepinephrine on postoperative outcomes in candidate patients for coronary artery bypass graft:RCT 2019-12-11 anticipated 123 Complete https://irct.ir/trial/48659 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, 123 patients were divided into three completely equal blocks using epinephrine, norepinephrine, and placebo at three times during sampling using software randomized blocking, Blinding description: After surgery, patients are divided into A B C groups. The first group is the placebo group, where normal saline is poured on the heart. Be. In all three groups, the drug is prepared in the same size and with the same color and shape for patients, which is acceptable in terms of blindness and blinding surgery. Also, the person in charge of the project, who is responsible for filling out the checklist, is not aware of the type of groups based on the injection drug, and only recognizes the groups based on A, B, and C, and fills the checklists accordingly. 3 Coronary artery bypass graft. Intervention 1: Control group: After the operation, 50 cc of normal saline is poured into the pericardium area alone and washed. Intervention 2: First Intervention group: After the operation: An epinephrine vial (1mg) is immersed in 50 cc of normal saline and poured into the pericardium. Intervention 3: Second intervention group: After surgery, half of the norepinephrine (2 mg) vial is immersed in 50 cc of normal saline and washed. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more informations
public Marjan Abdoli
Payambar-e-azam Complex, Basij Sq., Sardasht Town
Arak Iran (Islamic Republic of) 3848176341 +98 86 3417 3639 marjanabdoli13733731@gmail.com Arak University of Medical Sciences scientific Marjan Abdoli
Payambar-e-azam Complex, Basij Sq., Sardasht Town
Arak Iran (Islamic Republic of) 3848176341 +98 86 3417 3639 marjanabdoli13733731@gmail.com Arak University of Medical Sciences Iran (Islamic Republic of) Non-emergency CABG candidate patients who have agreed to participate in the project All patients with ASA class 3 and 4 All patients whose surgery duration is less than 6 hours 45 years 80 years Both Patients who underwent emergency CABG surgery Patients who do not have a consent to participate in the project Patients who, in addition to CABG, are candidates for valve replacement surgery Patients who had more than 6 hours of surgery I25.7 Atherosclerosis of coronary artery bypass graft(s) and coronary artery of transplanted heart with angina pectoris Placebo Treatment - Drugs Treatment - Drugs Control group: After the operation, 50 cc of normal saline is poured into the pericardium area alone and washed. First Intervention group: After the operation: An epinephrine vial (1mg) is immersed in 50 cc of normal saline and poured into the pericardium. Second intervention group: After surgery, half of the norepinephrine (2 mg) vial is immersed in 50 cc of normal saline and washed. Bleeding 24 hours after surgery. Timepoint: 24 hours after surgery. Method of measurement: Suction the amount of bleeding in the calibrated container. Lenght of stay at the ICU. Timepoint: When leaving the ICU. Method of measurement: Calculation from the date of surgery. Patient's hemoglobin level after surgery. Timepoint: After surgery. Method of measurement: Complete Blood Count. Arak University of Medical Sciences Approved 2019-01-13 Ethics committee of Arak University of Medical Sciences Payambar-e-Azam Complex, Sardasht Arak Markazi Iran (Islamic Republic of)