IRCT20200531047619N1 IRCT 2020-10-18 Iran University of Medical Sciences Evaluation of the effect of Tofacitinib in covid-19 patients Evaluation of the effect of Tofacitinib drug (Iranian brand of Rhofanib drug) on clinical and laboratory symptoms in severe and resistant patients with COVID-19 2020-08-21 anticipated 10 Complete https://irct.ir/trial/48766 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Other, Purpose: Treatment, Other design features: 1-The dose of this drug in patients with rheumatoid arthritis is 5 mg twice a day and in patients with covid-19 the same dose is used for 10 days. 2-In this study, 10 patients are used first, and if the effect of the drug is good in improving patients, the number will be higher. 3 Coronavirus disease (COVID-19). Intervention 1: Intervention group: This group includes severe and ill covid-19 patients who did not respond to routine and existing treatments.In these patients, the Iranian brand of drug tofacitinib or rhofanib is used and this drug is in the form of 5 mg tablets that are used orally twice a day for fourteen days and the manufacturer of this drug is Alvand Nanotechnology Company. Intervention 2: Control group: In this group, severe and ill COVID-19 patients are admitted to the ICU and received all the routine medications used in ill patients.Tofacitinib given in the intervention group is not given to the control group. Yes - There is a plan to make this available What will be shared: In this study, all data can be shared after identifying individuals. When: In this study, the data access time is six months after the results are published. To whom: The data of this study are available to researchers working in academic and scientific institutions and people working in industry. Conditions: There is no limit to the use of this data and the only condition is that this data be used to advance science and help patients. Where to obtain: For data, contact Simin Almasi at Firoozgar Hospital or email simin_almasi@yahoo.com. How to obtain: About 7 to 10 days after the announcement of the request to obtain the data, this data will be received by the applicant. Comments: I have no other explanation