]>
IRCT20200609047706N1 IRCT 2020-06-16 Esfahan University of Medical Sciences Citicoline on Barthel Index in Patients with Moderate and Severe Traumatic Brain Injury Effect of Citicoline on Barthel Index in Patients with Moderate and Severe Traumatic Brain Injury 2020-06-21 anticipated 80 Complete https://irct.ir/trial/48768 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: In this study, the patient do not know he/ she is in which group (case or control) and the researcher do not know case qroup in research time and the clinical care giver has a list about case group and do the intervention. 3 Patients with severe and moderate brain injury. Intervention 1: Case group: citicoline drug at a dose of 2000 mg oral twice daily by injection for 1 week and 2000 mg twice daily orally. Intervention 2: Control group: Taking placebo. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Mehdi Mahmoodkhani
Kashani Hospital, Kashani Ave
Isfahan Iran (Islamic Republic of) 8183983434 +98 31 3233 0091 mahmoodkhani@med.mui.ac.ir Esfahan University of Medical Sciences scientific Mehdi Mahmoodkhani
Kashani Hospital, Kashani Ave
Isfahan Iran (Islamic Republic of) 8183983434 +98 31 3233 0091 kashani@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Patients with severe and moderate traumatic brain injury based on GCS less than 12 Patients should be without traumatic major lesions in the thorax, abdomen, and limbs Patients without heart problems Have the satisfaction to enter the study no limit no limit Both Previous history of brain Injury, stroke, or neurological disease Contraindications or sensitivity to Citicoline The presence of comorbidities such as cardiovascular, renal, hepatic, and malignant history Traumatic brain injury, major trauma to the thorax, abdomen and other organs Unstable hemodynamics Pregnancy Surgical interventions were performed within the first 24 hours after trauma cardiopulmonary resuscitation was performed within the first 24 hours after trauma Dissatisfaction of the patient to enter the study and her/his death during the study S06.2X Diffuse traumatic brain injury Treatment - Drugs Treatment - Drugs Case group: citicoline drug at a dose of 2000 mg oral twice daily by injection for 1 week and 2000 mg twice daily orally Control group: Taking placebo Improving the patient's barthel index. Timepoint: Upon arrival, one month, three months and six months. Method of measurement: Barthel Questionnaire. Isfahan Approved 2020-05-02 Ethics committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciense, Hezarjarib Ave Isfahan Isfehan Iran (Islamic Republic of)