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IRCT201104134578N2 IRCT 2011-05-08 Hamedan University of Medical Sciences-vice chancellor for research Ranitidine and pantoprazole in prevention of stress ulcer The comparison of ranitidine and pantoprazole in prevention of stress ulcer in ICU 2011-02-20 anticipated 92 Complete https://irct.ir/trial/4878 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A stress ulcer. Intervention 1: In intervention group Pantoprazol 40 mg once a day will infuse till to end of patient admission. Intervention 2: In control group Ranitidine 50 mg twice a day will infuse till to end of patient admission.
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scientific Farshid Rahimi Bashar
Mahdiye Street, Hamedan University Of Medical Sciences
Hamedan Iran (Islamic Republic of) +98 81 1827 6295 fr_rahimibashar@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients who required mechanical ventilation, Age more than 18 years old, Admission to the ICU, APACHE SCORE II less than 25, Admission at least 24 hour in ICU, Patients with suctionable secretion, No GI bleeding at the beginning of study Exclusion criteria: History of GI bleeding, liver or kidney insufficiency, History of corticosteroids or NSAIDs usage, Gastric PH more than 4 before beginning of prophylaxis 18 years 90 years Both K25 Gastric ulcer Prevention Prevention In intervention group Pantoprazol 40 mg once a day will infuse till to end of patient admission. In control group Ranitidine 50 mg twice a day will infuse till to end of patient admission. Gastric PH. Timepoint: Before intervention, every 8 houres after intervention for two next days. Method of measurement: The level of gastric PH which is measured by AZ8685 PH metery instrument. GI bleeding. Timepoint: Daily. Method of measurement: Evaluating the secretion which lavaged from the patient NG tube to the end of admission in the ICU. Hamedan University of Medical Sciences-vice chancellor for research Approved 2011-04-07 Hamedan University Of Medical Sciences Mahdiye Street, Hamedan University Of Medical Sciences Hamedan Iran (Islamic Republic of)