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IRCT20200616047795N1 IRCT 2020-06-22 Birjand University of Medical Sciences Evaluation of the effect of vitamin D on diabetic patients Determining the effect of vitamin D on the expression of inflammatory NLRP3 genes and oxidative stress in Patients with type 2 diabetes 2019-06-22 anticipated 68 Complete https://irct.ir/trial/48956 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Other, Purpose: Prevention, Randomization description: Simple randomization, block, Blinding description: Individual participants are more likely to have vitamin D interventions Either Placebo was unaware, but they were well aware of the goals, methods, and beneficial consequences, and the potential dangers of studying, and the problems that could follow. Stop cooperating. And the doctor was aware of the participants' informed and free consent, and patients who were not at risk for drug intervention and people who were deficient in vitamin D were referred by a doctor, but the doctor did not know how the accident happened. Data collection officials and those assessing the outcome were unaware of the type and manner of intervention. 2-3 Type 2 diabetes with vitamin D deficiency. Intervention group: Vitamin D tablets (1 and 25 hydroxyvitamin D3), every week for 8 weeks at a dose of 50,000 units, a product of Zahravi Pharmaceutical Company (Tabriz). Yes - There is a plan to make this available What will be shared: Information about the main consequence or the like can be shared. When: Start the access period from 2021 and after printing the results To whom: It will be available for researchers working in academic and scientific institutions Conditions: In case of further study in this field and related studies Where to obtain: Birjand University of Medical Sciences, Central Library How to obtain: It must be pursued through the university Comments:
public Shadi
Ghaffari Street
birjand Iran (Islamic Republic of) 9717853577 +98 56 3238 1601 shadi.behshad@bums.ac.ir Birjand University of Medical Sciences scientific محمد
Ghaffari Street
birjand Iran (Islamic Republic of) 9717853577 +98 56 3238 1601 drmalekaneh@bums.ac.ir Birjand University of Medical Sciences Iran (Islamic Republic of) The disease (diabetes) has already been confirmed by a specialist. People with diabetes who have had diabetes for at least 5 years The criterion for entering the diabetic group is HbA1C, which is outside the normal range. Age range 50-65 years The desire to participate in the study 50 years 65 years Both Systemic diseases (rheumatoid arthritis ...) that can affect the results. Cancer Taking corticosteroids Thyroid disease Kidney diseases and adrenal glands Liver diseases Multivitamin consumption Treatment - Drugs Intervention group: Vitamin D tablets (1 and 25 hydroxyvitamin D3), every week for 8 weeks at a dose of 50,000 units, a product of Zahravi Pharmaceutical Company (Tabriz) Vitamin D levels. Timepoint: First and after 8 weeks. Method of measurement: Vitamin D will be measured with a little luminescence technique. HDL, LDL, A1C hemoglobin levels, Nlrp3 gene, and oxidative stress status. Timepoint: First and after 8 weeks. Method of measurement: Tests (LDL, HDL) are performed with kits and enzymatic methods. The A1C Hb will be measured using the immunomturbidometry technique. However, PCR real-time techniques are used for genetic testing, as well as tests for oxidative stress status with TAC antioxidant kits by FRAP, Thiol group, and MDA by spectrophotometry. Birjand University of Medical Sciences Approved 2019-07-23 Ethics committee of Birjand University of Medical Sciences Ghaffari Street Birjand South Khorasan Iran (Islamic Republic of)