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IRCT20190618043934N5 IRCT 2020-07-04 Birjand University of Medical Sciences The effect of diphenhydramine on adenotonsillectomy Comparison of diphenhydramine and placebo on the side effect of tonsillectomy 2020-06-19 anticipated 66 Complete https://irct.ir/trial/48996 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Participants in the study will be randomly divided into intervention and control groups using a random number table, Blinding description: Assessor of the outcome (nurse) without knowing the placement of the individual in the study group. 3 Tonsillitis. Intervention 1: Intervention group: Patients taking diphenhydramine as a anesthetic in the tonsil bed receive 1.25 mg / kg up to a maximum of 8 mg 5 minutes before surgery. Intervention 2: Control group: Normal saline patients receive the same amount of diphenhydramine in the tonsil bed 5 minutes before surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no need to publish individual patient information
public Zabihullah Mohaghegh
Moallaem St
Birjand Iran (Islamic Republic of) 9717811674 +98 56 3232 3232 oabstudent@gmail.com Birjand University of Medical Sciences scientific Dr MohammadReza Mofatteh
Ghaffari Str
Birjand Iran (Islamic Republic of) 9717811674 +98 56 3232 3232 oabstudent@gmail.com Birjand University of Medical Sciences Iran (Islamic Republic of) Age between 5 and 50 years Patients with ASA classes 1 and 2 No history of liver disease Lack of bronchial asthma Lack of bladder disease No pregnancy and lactation Lack of blood pressure during pregnancy or preeclampsia No history of kidney disease 5 years 50 years Both Coagulation disorder Simultaneous surgery of the patient with other oral and pharyngeal problems Allergic reactions known to antihistamines Allergic reactions known to benzodiazepines or topical anesthetics Having an acute pharyngeal infection J03 Acute tonsillitis Treatment - Drugs Placebo Intervention group: Patients taking diphenhydramine as a anesthetic in the tonsil bed receive 1.25 mg / kg up to a maximum of 8 mg 5 minutes before surgery. Control group: Normal saline patients receive the same amount of diphenhydramine in the tonsil bed 5 minutes before surgery. Pain. Timepoint: 0, 6, 12 and 24 hours after surgery. Method of measurement: Using the VAS Scale. Birjand University of Medical Sciences Approved 2020-06-10 Ethics Committee of Birjand University of Medical Sciences Moallem BLV Birjand South Khorasan Iran (Islamic Republic of)