IRCT20130304012695N7 IRCT 2020-07-21 Tehran University of Medical Sciences control catheter bladder discomfort Evaluation of the preventive effect of intravenous diphenhydramine injection before induction of anesthesia on control of the catheter bladder discomfort after Nephrolithiasis surgery 2019-08-23 anticipated 76 Complete https://irct.ir/trial/49087 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: To randomize patients with inclusion criteria Block balanced randomization is used.Before studying, one of the person who is not a member of the research team performs the randomization process by using Random generator software, forms four blocks for the intervention and control group. The complete cards of the four blocks are given to the head of the operating room, who is unaware of the study, in an envelope. A card is given to the patient after patient entrance to operating room, Blinding description: Participants. Those who evaluate the outcome. Data collection officials. 2-3 catheter bladder discomfort. Intervention 1: Intervention group: 50 mg of diphenhydramine is injected intravenously before anesthesia and the degree of agitation, pain, and hemodynamic changes during extubation, and the incidence and severity of catheter bladder discomfort in the recovery and the total amount of analgesic reqiurement are evaluated during 24 hours after surgery. Intervention 2: Control group: They do not receive medication and the degree of agitation, pain, and hemodynamic changes during extubation, and the incidence and severity of catheter bladder discomfort in the recovery and the total amount of analgesic reqiurement are evaluated during 24 hours after surgery. Yes - There is a plan to make this available What will be shared: All information used for this research can be shared after unidentified the identity of patients. Also, statistical information, information analysis, study method, findings and conclusions can be shared. When: Starting access after accepting by a valid scientific journal and publishing it To whom: For academic researchers and in the field of science Conditions: All researchers can use all published material and if all or part of this research is published by other people, the name and source of this research and its researchers should be mentioned. Where to obtain: Mohammad Reza Khajavi khajavim@tums.ac.ir How to obtain: The applicant can request the type of files by email. Comments: