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IRCT20141209020258N145 IRCT 2020-07-05 Arak University of Medical Sciences Comparison of magnesium sulfate and dexmedetomidine and ondansetron ‎supplementation with lidocaine for pre-laryngoscopic and tracheal intubation ‎gargling in prevention of sore throat and control of hemodynamic changes Comparison of magnesium sulfate and dexmedetomidine and ondansetron ‎supplementation with lidocaine for pre-laryngoscopic and tracheal intubation ‎gargling in prevention of sore throat and control of hemodynamic changes 2020-04-18 anticipated 105 Complete https://irct.ir/trial/49094 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple individual randomization with randomization with envelopes in 3 groups A and B and C . In this method, we write a few cards or letters as intervention groups and the same ‎number of cards for the control group, then the cards are mixed. One card is taken out and its ‎allocation is registered and the card is returned to the other cards after leaving. Then the cards ‎are mixed again and then another card is picked up. This process continues to reach a random sequence ‎according to sample size, Blinding description: This study is double blind. Outcome elevator and analyzer and participant are blind. Outcome elevator and analyzer and participant don't aware from grouping.Drug sets will be covered with foil. After calculating the amount and prescribed at the desired dose. 3 Sore throat. Intervention 1: Intervention group: Patients will grunt 2 gram Magnesium Sulfate 20 percent (Shahid ghazi Co) plus 100 milligram Lidocaine and 5 millilitre Dextrose 20 percent. Intervention 2: Intervention group: atients will grunt 1 microgram Dexmedetomidine (Exir Co) plus 100 milligram Lidocaine and 5 millilitre Dextrose 20 percent. Intervention group. Intervention 3: Intervention group: Patients will grunt 4 milligram Ondansetron (Exir Co) plus 100 milligram Lidocaine and 5 millilitre Dextrose 20 percent. Yes - There is a plan to make this available What will be shared: When we publish article in journal When: After the article is published To whom: Researcher in university Conditions: If there are additional questions Where to obtain: Dr Hesamodin Modir How to obtain: They have to write letters to the professors and the university. Comments:
public Dr Shirin Pazuki
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 pazuki@arakmu.ac.ir Arak University of Medical Sciences scientific Dr Hesamedin Modir
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 modir.he@gmail.com Arak University of Medical Sciences Iran (Islamic Republic of) 30 to 60 years ASA class 1 and 2 No history of sore throat before surgery No history of head and neck surgery, especially of the throat No history of drug use No history of chronic housing use Lack of sensitivity to the drugs used in this study Lack of upper airway infection and cold Malampati more than 2 Lack of liver and kidney failure No need to use NG-tube during surgery and up to 24 hours after surgery The duration of surgery should not be less than 45 minutes and not more than 120 minutes 30 years 60 years Both Patient dissatisfaction with continuing to study Observation of blood during suction when removing the tracheal tube For whatever reason, we have to have laryngoscopy twice J02.9 Acute pharyngitis, unspecified Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: Patients will grunt 2 gram Magnesium Sulfate 20 percent (Shahid ghazi Co) plus 100 milligram Lidocaine and 5 millilitre Dextrose 20 percent. Intervention group: atients will grunt 1 microgram Dexmedetomidine (Exir Co) plus 100 milligram Lidocaine and 5 millilitre Dextrose 20 percent. Intervention group Intervention group: Patients will grunt 4 milligram Ondansetron (Exir Co) plus 100 milligram Lidocaine and 5 millilitre Dextrose 20 percent. Sore throat. Timepoint: In recovery and 2, 4, 8, 12 and 24 hours after surgery. Method of measurement: Observation. Hoarseness. Timepoint: In recovery and 2, 4, 8, 12 and 24 hours after surgery. Method of measurement: Observation. Cough. Timepoint: In recovery and 2, 4, 8, 12 and 24 hours after surgery. Method of measurement: Observation. Arak University of Medical Sciences Approved 2020-05-17 Ethics comittee of Arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)