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IRCT20181208041882N3 IRCT 2020-11-06 Yazd University of Medical Sciences Evaluation of curcumin gel effevtiveness in prophylaxis of radiation dermatitis Evaluation of 2% curcumin gel effevtiveness in prophylaxis of radiation dermatitis 2019-06-16 anticipated 60 Complete https://irct.ir/trial/49228 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: In this study, simple randomization method was used. Patients were randomly assigned to two groups by using Random.org site, Blinding description: In this study patients, clinical caregivers and outcome assessors were unaware of the type of medication patients were receiving. Patients in both groups received the medication in the same package. 3 Dermatitis caused by breast radiation therapy. Intervention 1: Intervention group: Curcumin gel 2% twice daily from the first day Radiation therapy The patient receives one of the same gels topically for four weeks. Made in Yazd University of Medical Sciences. Intervention 2: Control group: Placebo gel twice daily from the first day Radiation therapy The patient receives one of the same gels topically for four weeks. Made in Yazd University of Medical Sciences. Yes - There is a plan to make this available What will be shared: After nonrecognition all data can be share When: 6 months after publication To whom: All of researchers Conditions: Nothing Where to obtain: Dr.Behrooz Heydari email :b.heydari@ssu.ac.ir How to obtain: Request your informationby email :The data will be sent after a week Comments:

public Behrooz Heydari

Shahid Sadoughi University of medical sciences Shohadaye Gomnam Blv Alem Sq

Yazd Iran (Islamic Republic of) 8915173143 +98 35 3820 3410 b.heydari@ssu.ac.ir Yazd University of Medical Sciences scientific Behrooz Heydari

Shahid Sadoughi University of medical sciences Shohadaye Gomnam Blvd Alem Sq

Yazd Iran (Islamic Republic of) 8915173143 +98 35 3830 3410 b.heydari@ssu.ac.ir Yazd University of Medical Sciences Iran (Islamic Republic of) Women 18 to 65 years old to get started breast radiation therapy has been referred to Shahid Ramezanzadeh Radiotherapy Center in Yazd 18 years 65 years Female People with skin diseases People who are allergic to curcumin People with severe systemic diseases such as uncontrolled diabetes L58 Radiodermatitis Prevention Placebo Intervention group: Curcumin gel 2% twice daily from the first day Radiation therapy The patient receives one of the same gels topically for four weeks. Made in Yazd University of Medical Sciences Control group: Placebo gel twice daily from the first day Radiation therapy The patient receives one of the same gels topically for four weeks. Made in Yazd University of Medical Sciences Intensity of redness. Timepoint: The severity of the redness begins with treatment Redness intensity in the first week Redness intensity in the second week Redness intensity in the third week and redness intensity in the fourth week after starting treatment. Method of measurement: RTOG standard scale. Itching intensity. Timepoint: The severity of itching begins treatment Severity of itching in the first week Severity of itching in the second week Severity of itching in the third week and severity of itching in the fourth week after starting treatment. Method of measurement: Based on a question from the patient. Intensity of burning. Timepoint: Severe onset of burning of treatment of severity of burning in the first week, severity of burning in the second week, severity of burning in the third week, and severity of burning in the fourth week after starting treatment. Method of measurement: Based on a question from the patient. Intensity of pain. Timepoint: Intensity of pain Initiation of treatment Intensity of pain The first week Pain intensity in the second week Pain intensity in the third week and pain intensity in the fourth week after starting treatment. Method of measurement: Based on a question from the patient. دانشگاه علوم پزشکی یزد Approved 2019-02-06 Ethics committee of yazd university of medical sciences Shahid Sadoughi University of medical sciences Shohadaye Gomnam Blve Alem Sq Yazd Yazd Iran (Islamic Republic of)