IRCT20120716010297N7 IRCT 2020-07-11 Esfahan University of Medical Sciences Comparison of the effect of methotrexate dose in the treatment of patients with ectopic pregnancy Comparison of single-dose and multi-dose methotrexate in the treatment of patients with ectopic pregnancy 2017-06-22 anticipated 108 Complete https://irct.ir/trial/49305 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: First, eligible patients will be selected using non-probability consecutive. All the patients will randomly be assigned to two intervention groups using a computer-based random digit generator based on the consecutive admission numbers, Blinding description: Because of the use of different doses of the drug, the researcher is aware of the type of each group, but the person following the patient's condition and the statistician will not be aware of the type of group. 2-3 Ectopic pregnancy. Intervention 1: Intervention group: In the multi-dose regimen, 1 mg / kg methotrexate will be injected on days of 1, 3, 5, and 7. It should be noted that in these days, βHCG titer will be measured before methotrexate injection, and methotrexate is prescribed if there was no reduction of less than 15%. Leucovorin will be injected at a dose of 0.1 mg / kg on days 2, 4, 6, and 8. Intervention 2: Intervention group: In the single-dose regimen after methotrexate injection, βHCG titers will be evaluated on days 4 and 7. If no reduction of 15% in βHCG titer was observed during this period, an additional dose will be injected on the seventh day. The dose of methotrexate in the single-dose method is 50 mg/m2 intramuscularly and is not require Leucovorin injection. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information