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IRCT20181203041838N2 IRCT 2020-12-02 Esfahan University of Medical Sciences Efficacy of high-flow nasal cannula oxygen therapy in acute respiratory failure Efficacy of high-flow nasal cannula oxygen therapy in acute respiratory failure Compared with conventional O2 therepy 2020-08-22 anticipated 99 Complete https://irct.ir/trial/49393 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this randomized parallel groups design, patients who fulfill the inclusion criteria are selected and by permuted block randomization of blocks size 2 randomly divided into 2 groups ( intervention and control). Patients are individually assigned to 2 groups and both groups are equal in number( 33 patient in each group). Random sequence generation will be done by SPSS statistical software and random sequence concealment will be done by sealed envelopes. N/A Respiratory Failure. Intervention 1: Intervention group: High pressure oxygen therapy (60 lit per min o2) In this study Patients with r espiratory failure are admitted to the emergency department. initially they are treated with ordinary oxygen with a nasal cannulla for at least 15 minutes.then in case of no recovery and no increase in Sat O2 in pulseoxymetry patients will be divided into two groups Randomly. They will be treated with high-flow oxygen(up to 60 lit per min) or continue with regular oxygen(up to 10-15 lit per min) .A group of patient used High pressure oxygen for an hour will be compared in O2 sat increse , the amount of need for intubation and the rate of ICU admission with the group that they continue with regular oxygen.(Emergency personnel have already participated in training coarse on how to work with devises.). Intervention 2: Control group: nasal cannula oxygen therapy( 10-15 lit per min o2). Intervention 3: Intervention group: BIPAP non invasive mechanical ventilation(bipap) is also used in this study to comparison approach of high flow o2 and BIPAP . a group of 33 patients with BIPAP will be intervented. they will be compared based on respiratory status , the amount of PCO2 in VBG( before and after treatment ) and need to intubation or ICU addmition. Yes - There is a plan to make this available What will be shared: All data is shared after people are not identified When: Start of access period from 2022 To whom: Researchers working in academic and scientific institutions Conditions: for research Where to obtain: m_nasr@med.mui.ac.ir How to obtain: Request via email Comments:
public Mohammad Nasr-Esfahani
hezar jerib st
esfahan Iran (Islamic Republic of) 8174673461 +98 31 3792 3071 m_nasr@med.mui.ac.ir Esfahan University of Medical Sciences scientific Mohammad Nasr-Esfahani
Soffeh Blvd
isfahan Iran (Islamic Republic of) 8174675731 +98 31 3625 5555 m_nasr@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Patient with acute respiratory failure 18 years no limit Both Unstable hemodynamic Loss of consciousness Obesity hypoventilation syndrome J96.0 Acute respiratory failure Treatment - Devices Treatment - Other Treatment - Devices Intervention group: High pressure oxygen therapy (60 lit per min o2) In this study Patients with r espiratory failure are admitted to the emergency department. initially they are treated with ordinary oxygen with a nasal cannulla for at least 15 minutes.then in case of no recovery and no increase in Sat O2 in pulseoxymetry patients will be divided into two groups Randomly. They will be treated with high-flow oxygen(up to 60 lit per min) or continue with regular oxygen(up to 10-15 lit per min) .A group of patient used High pressure oxygen for an hour will be compared in O2 sat increse , the amount of need for intubation and the rate of ICU admission with the group that they continue with regular oxygen.(Emergency personnel have already participated in training coarse on how to work with devises.) Control group: nasal cannula oxygen therapy( 10-15 lit per min o2) Intervention group: BIPAP non invasive mechanical ventilation(bipap) is also used in this study to comparison approach of high flow o2 and BIPAP . a group of 33 patients with BIPAP will be intervented. they will be compared based on respiratory status , the amount of PCO2 in VBG( before and after treatment ) and need to intubation or ICU addmition. Increase in blood oxygen saturation level. Timepoint: Measuring the percentage increase in blood oxygen saturation level after one hour. Method of measurement: Pulse Oximetry. Esfahan University of Medical Sciences Approved 2020-06-23 Ethics committee of Isfahan University of Medical Sciences Hezar jerib Isfahan Isfehan Iran (Islamic Republic of)