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IRCT20200705048020N1 IRCT 2020-09-07 Yazd University of Medical Sciences Evaluation the effect of Pentoxifylline on spermatozoa of Azoospermic patients Comparison of the effect of pentoxifylline on sperm structure ,embryo morphokinetics resulting from these sperms and clinical outcomes compared to the control group in azoospermic patients 2021-02-26 anticipated 40 Complete https://irct.ir/trial/49441 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 4 azoospermia. Intervention 1: Intervention group: Addition of 3.6 mmol pentoxifylline to a drop of containing sperm sample and selection of motile sperm. Intervention 2: Control group: No intervention is made. Yes - There is a plan to make this available What will be shared: Data: 1) Fertility rate, by examining the formation of proonucleus in the egg cell 2) Checking the embryo quality and morphokinetic using time lapse system and calculating the time related to the process of cell division of the embryo 3) Checking the chemical and clinical pregnancy rates respectively one week and 7 weeks after embryo transfer When: Up to one year after publication of the article To whom: Researchers working in academic and scientific institutions Conditions: With the re-consent of the participant and the researcher responsible of the project Where to obtain: mohammad ali khalili 09133570876 khalili59@hotmail.com How to obtain: Send a request via email to the responsible researcher Comments:
public mohammad ali khalili
Bouali street,Safaieh
yazd Iran (Islamic Republic of) 8916877391 +98 35 3824 8119 khalili59@hotmail.com Yazd University of Medical Sciences scientific mohammad ali khalili
Bouali street,Safaieh
yazd Iran (Islamic Republic of) 8916877391 +98 35 3824 7085 khalili59@hotmail.com Yazd University of Medical Sciences Iran (Islamic Republic of) All non obstructive azoospermia patients less than 50 years old and more than 50 number sperm women less than 40 years old without any Infertility problems 20 years 50 years Male HIV- positive patient with any pathology Patients with very low sperm count women more than 40 years old Couples who also have problems with female infertility N46 Male infertility Treatment - Drugs Treatment - Other Intervention group: Addition of 3.6 mmol pentoxifylline to a drop of containing sperm sample and selection of motile sperm Control group: No intervention is made Fertilization rate. Timepoint: One day after assisted artificial insemination. Method of measurement: formation of 2 pronucleous. Embryo formation rate. Timepoint: 3 days after assisting artificial insemination. Method of measurement: 8 cell embryo formation. Embryo morphokinetic rate. Timepoint: From the time of pronucleous formation until the time of embryo transfer to the mother's uterus. Method of measurement: Time Lapse Incubator. Chemical pregnancy rate. Timepoint: One week after the embryo transfer to the uterus. Method of measurement: Blood βHCG Measurement. Clinical pregnancy rate. Timepoint: 7 weeks after embryo transfer to the uterus. Method of measurement: Assessment of cardiovascular formation using ultrasound examination. Yazd University of Medical Sciences Approved 2019-08-26 Ethics Committee of Yazd University of Medical Sciences Research Institute of Reproductive Sciences,Bouali St., Safaieh yazd Yazd Iran (Islamic Republic of)