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IRCT20200705048006N1 IRCT 2020-08-03 Mashhad University of Medical Sciences Comparison of the effect of Myrtus herbal mouthwash versus chlorhexidine mouthwash on the prevention of Ventilator Associated Pneumonia Comparison of the effect of Myrtus herbal mouthwash versus chlorhexidine mouthwash on the prevention of Ventilator Associated Pneumonia 2020-09-21 anticipated 70 Complete https://irct.ir/trial/49465 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Using a random sequence generated by SPSS software that is written on small cards and kept in an envelope in a package. After confirming the entry of each research unit into the study, the envelope is opened and based on the entered code, the patient enters one of the two groups, Blinding description: - Participants in this study are unconscious patients and their primary caregiver is unaware of the type of mouthwash used for them. Therefore, the patient's primary caregiver is blind to the intervention. - After data collection by one researcher, statistical analysis will be performed by another person who does not know the type of intervention and data related to each group. N/A Ventilator Associated Pneumonia. Intervention 1: Intervention group: The intervention group receives oral care with the herbal mouthwash for 5 days and three times a day by the same method by the researcher. Other care will be the same in both groups.This mouthwash is a leaf extract of the plant with a concentration of 5%, which will be prepared and calibrated by the Faculty of Traditional and Complementary Medicine. Intervention 2: Control group: Oral care with chlorhexidine mouthwash 0.2% of the construction of Iran Najo Pharmaceutical Factory, which will be poured in 30 cc, will be received by the researcher in the same way for 5 days and three times a day. Yes - There is a plan to make this available What will be shared: All potential data can be shared after people have not been identified When: 6 months after printing the results To whom: Only for researchers working in academic and scientific institutions Conditions: The data can be used for other human research and health centers Where to obtain: Library of Mashhad School of Nursing and Midwifery How to obtain: By visiting the library of Mashhad School of Nursing and Midwifery in person or online Comments:
public Ali Farahmand Nasab
Mashhad, Ibn Sina Street, School of Nursing and Midwifery
Mashhad Iran (Islamic Republic of) 9137913199 +98 51 3859 1511 FarahmandNA961@mums.ac.ir Mashhad University of Medical Sciences scientific علی فرهمند نسب
Mashhad, Ibn Sina Street, School of Nursing and Midwifery
Mashhad Iran (Islamic Republic of) 9137913199 +98 51 3859 1511 FarahmandNA961@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) The main caregiver of the patient should be consciously satisfied to participate in the research (due to the disorder in the patient's level of consciousness) The patient's age should be between 70-18 years Immunosuppressive diseases and underlying lung disease are not recognized by the treating physician Do not have a specific lesion in or around the mouth Has no history of allergy to herbal ingredients (according to the history obtained from the patient's primary caregiver) Under mechanical ventilation through the endotracheal tube At the time of hospitalization in the ICU and intubation, there is no evidence of pneumonia in chest radiography at the discretion of the treating physician Must be mechanically ventilated for at least the next 48 hours (according to the definition of Ventilator Associated Pneumonia) 18 years 70 years Female Withdrawal of the patient's primary caregiver from continuing the study Transfer or death of the patient, removal of the endotracheal tube before 48 hours Allergic reaction to mouthwash Observation of obvious aspiration (observation of gastric material during endotracheal tube suction, change of position, cough, etc.) Do not have an upper airway infection (based on your doctor's diagnosis) J00-J99 Diseases of the respiratory system:pneumonia Treatment - Drugs Treatment - Drugs Intervention group: The intervention group receives oral care with the herbal mouthwash for 5 days and three times a day by the same method by the researcher. Other care will be the same in both groups.This mouthwash is a leaf extract of the plant with a concentration of 5%, which will be prepared and calibrated by the Faculty of Traditional and Complementary Medicine. Control group: Oral care with chlorhexidine mouthwash 0.2% of the construction of Iran Najo Pharmaceutical Factory, which will be poured in 30 cc, will be received by the researcher in the same way for 5 days and three times a day. Prevention of Ventilator Associated Pneumonia. Timepoint: Before the intervention and the fifth day after the intervention. Method of measurement: Clinical Pulmonary Infection Scale. Mashhad University of Medical Sciences Approved 2020-07-06 Ethics Committee of Mashhad University of Medical Sciences Ibn Sina Avenue, Faculty of Nursing and Midwifery Mashhad Razavi Khorasan Iran (Islamic Republic of)