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IRCT20200428047229N2 IRCT 2020-07-15 Shahid Beheshti University of Medical Sciences The effect of compound honey syrup on the airways of cystic fibrosis patients Fractional exhalation Nitric Oxide The efficacy of compound honey syrup on Fractional exhalation Nitric Oxide (FeNO) changes in Cystic Fibrosis patients 2020-06-29 anticipated 30 Complete https://irct.ir/trial/49518 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 3 Cystic fibrosis. Intervention group: After receiving informed consent from the parents of patients and children over 6 years of age, all standard and required drugs for cystic fibrosis patients are prescribed and in addition to the above treatments, the compound honey syrup is also prescribed. In the first visit (before starting the syrup) FeNO test, weight and height are taken from the patients and sputum culture is requested. Then compound honey syrup, 5-10 cc (depending on the age and weight of children) in 100 CC of boiled and lukewarm water is administered twice a day for 30 minutes after a meal for 6 weeks, and in weeks 2 and 4, the patient is followed up for the correct use of the drug. At 6 weeks, the patient is visited again, and the drugs and syrup are prescribed again for 6 weeks, and after that, the patient is followed up in the 8th and 10th weeks in terms of proper drug use. Finally, The patient is visited again in the 12th week, and FeNO test, weight and height are taken from the patients and also sputum culture is requested.. Yes - There is a plan to make this available What will be shared: Publishing results in the form of a Ph.D. thesis, an article indexing in ISI, and an article indexing in Pub Med When: After Ph.D. thesis defense To whom: Public Conditions: For research reasons Where to obtain: Shahid Beheshti University of Medical Sciences How to obtain: Approving by the responsible officer Comments:

public Hanieh Tahermohammadi

Faculty of Traditional Medicine, Shams Alley, Tavanir Station, Valiasr St., Tehran Town

Tehran Iran (Islamic Republic of) 1516745811 +98 21 8877 3521 dr.hmohammadi@sbmu.ac.ir Shahid Beheshti University of Medical Sciences scientific Shahpar Kaveh Bagh Bahadorani

Faculty of Traditional Medicine, Shams Alley, Tavanir Station, Valiasr St., Tehran Town

Tehran Iran (Islamic Republic of) 1516745811 +98 21 8877 3521 skaveh83@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) All cystic fibrosis patients over 6 years of age should be referred to the pulmonary clinic of Mofid Children's Hospital, diagnosed by a pediatric lung specialist. Conscious consent of parents of children and children over 6 years of age 6 years no limit Both Cystic fibrosis patients under 6 years of age referred to the pulmonary clinic of Mofid Children's Hospital Patients in need of hospitalization Patients who have attack symptoms of the disease (increased cough, sputum, fever, and need for hospitalization). Patients with underlying diseases such as allergic bronchopulmonary aspergillosis, heart failure and tuberculosis. Patients with other acute illnesses during treatment. Patients who are allergic to any of the components of the compound honey syrup. Patients who have decided to leave the study at their own request. Patients who are unable to co-operate with the FeNO test. E84 Cystic fibrosis Treatment - Drugs Intervention group: After receiving informed consent from the parents of patients and children over 6 years of age, all standard and required drugs for cystic fibrosis patients are prescribed and in addition to the above treatments, the compound honey syrup is also prescribed. In the first visit (before starting the syrup) FeNO test, weight and height are taken from the patients and sputum culture is requested. Then compound honey syrup, 5-10 cc (depending on the age and weight of children) in 100 CC of boiled and lukewarm water is administered twice a day for 30 minutes after a meal for 6 weeks, and in weeks 2 and 4, the patient is followed up for the correct use of the drug. At 6 weeks, the patient is visited again, and the drugs and syrup are prescribed again for 6 weeks, and after that, the patient is followed up in the 8th and 10th weeks in terms of proper drug use. Finally, The patient is visited again in the 12th week, and FeNO test, weight and height are taken from the patients and also sputum culture is requested. Fractional exhalation Nitric Oxide. Timepoint: At the beginning of the study (before the start of the intervention) and the twelfth week after the start of the compound honey syrup. Method of measurement: FeNO monitor (NObreath®). Weight. Timepoint: At the beginning of the study (before the start of the intervention) and the twelfth week after the start of the compound honey syrup. Method of measurement: Scales. Height. Timepoint: At the beginning of the study (before the start of the intervention) and the twelfth week after the start of the compound honey syrup. Method of measurement: Standing position and by meters. Body Mass Index (BMI). Timepoint: At the beginning of the study (before the start of the intervention) and the twelfth week after the start of the compound honey syrup. Method of measurement: Weight/(height)2. Staphylococcus aureus bacterial culture. Timepoint: At the beginning of the study (before the start of the intervention) and the twelfth week after the start of the compound honey syrup. Method of measurement: Preparation of sputum or throat swab after chest physiotherapy in the absence of sputum. Pseudomonas aeruginosa bacterial culture. Timepoint: At the beginning of the study (before the start of the intervention) and the twelfth week after the start of the compound honey syrup. Method of measurement: Preparation of sputum or throat swab after chest physiotherapy in the absence of sputum. Shahid Beheshti University of Medical Sciences Approved 2020-06-28 کمیته اخلاق دانشگاه علوم پزشکی شهید بهشتی خیابان یمن، دانشگاه علوم پزشکی شهیدبهشتی تهران Tehran Iran (Islamic Republic of)