IRCT20200710048068N1 IRCT 2022-06-21 Tehran University of Medical Sciences Efficacy of melatonin for the treatment of moderate to severe vincristine-induced neuropathy in pediatric malignancies Efficacy of melatonin for the treatment of moderate to severe vincristine-induced neuropathy in pediatric malignancies 2022-04-09 anticipated 20 Complete https://irct.ir/trial/49575 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization method of this study is permuted block randomization individually. The randomized list of numbers 1 to 20 is randomly divided into two groups A or B, and the admitted patients are listed in group A or B, respectively, Blinding description: This study is a two blind clinical trial conducted at children's medical center. The producing company were asked to produce the melatonin pills and placebo pills with the same app so that they are indistinguishable from each other. The drugs were delivered to the researcher in 2 separate packages (packet number 1 and packet number 2), One packet was a placebo pill and the other was a melatonin pill. In a sealed letter the content of each group were revealed. Patients, researcher and statistic expert were blinded. 3 chemotherapy induced neuropathy. Intervention 1: Intervention group: Patients receive melatonin (weight less than 40 kg: 3 mg, weight more than 40 kg: 5 mg) for 30 days 4 hours before bedtime and after dinner. Intervention 2: Control group: Patients receive placebo for 30 days 4 hours before bedtime and after dinner. Yes - There is a plan to make this available What will be shared: The data like check list and demographic data will be published in form of article. When: At the end of study and after publication To whom: Scientific researchers Conditions: For more researches Where to obtain: Toktam Faghihi How to obtain: After acceptance by Toktam Faghihi Comments: