IRCT20200628047940N1 IRCT 2020-07-21 Shiraz University of Medical Sciences Effect of probiotic in pediatric cholestatic liver disease Effect of probiotic (Lactobacilus sporogenesis) in reducing PELD score in pediatric cholestatic liver disease:Randomized double blinded clinical trial 2020-08-05 anticipated 120 Complete https://irct.ir/trial/49608 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The convince sampling method is goal-based. In this way, the researcher is present at the site during the study and starts sampling from the referring patients in an accessible way to get the total sample size. Randomization method: permutation block design or quadruple blocks will be used, Blinding description: The physician will examine the patient and evaluate the laboratory tests under blinded conditions.The case and control groups are also unaware of the nature of the drops (probiotic, and placebo). 3 Cholestatic liver disease in children. Intervention 1: Intervention group: The treatment group will be received Lactobacilus sporogenesis probiotic is given in drops for 1 month (5 drops per day in two intervals). Intervention 2: Control group: placebo drops is given in drops for 1 month (5 drops per day in two intervals) to control group. No - There is not a plan to make this available Justification or reason for not sharing IPD is The patients selected by convince sampling