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IRCT20140705018373N5 IRCT 2020-11-11 Tabriz University of Medical Sciences Effect of both PRP and 15% AHA versus 15% AHA alone on facial wrinkles Comparison of the therapeutic response of both PRP and 15% AHA versus 15% AHA alone in patients with facial wrinkles 2020-09-22 anticipated 60 Complete https://irct.ir/trial/49802 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Factorial, Purpose: Treatment, Randomization description: Randomization done using the file number of patients by site www.random.org and the Gaussian order. According to the study method, all patients will receive 15% AHA treatment and will be added in a PRP group. The cost of 15% AHA is part of the treatment routine, but the cost of PRP will be done in one group from the place of study costs. Therefore, additional costs are not borne by patients. 3 Facial wrinkles. Intervention 1: Intervention group: Patients will receive 15% alpha-hydroxy acid overnight topically with platelet-rich plasma injection every two months for 6 months. Intervention 2: Control group: Patients will receive 15% alpha-hydroxy acid topically overnight for 6 months. Yes - There is a plan to make this available What will be shared: Study data is categorized and coded with no identifiable individuals. When: Access to study data after publication of the result is available in the journal. To whom: Anyone interested in using the data can access the study data. Conditions: Study data can be used for comparison with other results. Where to obtain: Refer to the study's scientific or public accountability person for data. How to obtain: The request will be sent by email to person responsible for scientific or public inquiries. Comments:
public Dr. Mohammadreza Ranjkesh
Sina hospital, Azadi Ave., Tabriz town, East Azarbyjan
Tabriz Iran (Islamic Republic of) 5163639888 +98 41 3549 8236 ranjkeshm@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Dr. Mohammadreza Ranjkesh
Sina hospital, Azadi Ave., Tabriz town, East Azarbyjan
Tabriz Iran (Islamic Republic of) 5163639888 +98 41 3549 8236 ranjkeshm@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Age between 18 to 45 years Satisfaction to participate in the study 18 years 45 years Both Platelet disorder or blood clots Chronic liver disease Autoimmune diseases History of drug treatment with bleeding or clotting mechanisms, Having cosmetic treatments in the past 6 months Pregnancy Treatment - Drugs Treatment - Drugs Intervention group: Patients will receive 15% alpha-hydroxy acid overnight topically with platelet-rich plasma injection every two months for 6 months. Control group: Patients will receive 15% alpha-hydroxy acid topically overnight for 6 months. Facial wrinkles severity. Timepoint: Initiation of the study, 1, 3 and 6 months after the intervention. Method of measurement: Wrinkle Severity Rating Scale. Degree of tissue healing and homogeneity of facial skin. Timepoint: Initiation of the study, 1, 3 and 6 months after the intervention. Method of measurement: Skin Homogeneity and Texture Scale. Patient satisfaction. Timepoint: 6 months after the intervention. Method of measurement: Asking from patients on a scale of 1 to 5 range from very dissatisfied to very satisfied. Tabriz University of Medical Sciences Approved 2020-09-28 Ethics committee of Tabriz University of Medical Sciences Sina hospital, between Hafez and Shahid-Montazeri square, Azadi street Tabriz East Azarbaijan Iran (Islamic Republic of)