IRCT20200719048138N1 IRCT 2020-10-19 Iran University of Medical Sciences Evaluation of effect of fluoxetine on the clinical prognosis in patients with Optic neuritis Evaluation of effect of treatment by fluoxetine on clinical prognosis in patients with Optic neuritis in comparison between drug and placebo groups. 2019-10-04 anticipated 100 Complete https://irct.ir/trial/49900 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Other, Purpose: Treatment, Randomization description: In order to randomize allocation of patients in each group of study, we'll use the permuted block randomization method by means of blocks with 4 in size. According to the number of patients in each group of study (50 patients in each group and over all 100 cases in the study), 25 blocks of four by means of online website (www.sealedenvelope.com) will produce. For concealment, during randomization we'll use specific codes written on drug or placebo boxes which have been produced by computer. Each patient who enters the study will receive a box of drug or placebo according to the, Blinding description: During this study, participant will not be aware about if he receiving the drug or placebo because the shape and other features of boxes of both drugs and placebos are the same. The interviewer and investigator also will not be aware of which patients have received drug or placebo. But the analyzer knows the patients who received drug and the patients who received placebo. 3 The Optic neuritis. Intervention 1: Intervention group: Intervention group: receivers of fluoxetine antidepressant, 20 mg daily for 6 month. Intervention 2: Control group: Control group: Receivers of placebo of fluoxetine that are resemble exactly in appearance features to fluoxetine for 6 month. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is there is no further information