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IRCT20200726048213N1 IRCT 2020-08-12 Islamic Azad University of Rasht branch Effect of Aerobic Training and Pomegranate Juice in Breast Cancer Effect of Aerobic Training and Pomegranate Juice on micRNAs levels associated with Oxidant-Antioxidant Systems in Survivors of Breast Cancer 2019-11-23 anticipated 60 Complete https://irct.ir/trial/49929 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: In this study, the simultaneous effects of airobic training and Pomegranate juice consumtion has been investigated on progression of Breast cancer by monitoring some of the microRNAs and oxidant agents associated with cancer. N/A Breast Cancer. Intervention 1: Intervention group: aerobic exercise with Stationary Bike, 60 to 90 minutes, 3 sessions per week, for 8 weeks. Intervention 2: Intervention group: Natural pomegranate juice, 100 cc, fasting every morning, for 8 weeks. Intervention 3: Intervention group: aerobic exercise and pomegranate juice, 60 to 90 minutes of exercise, 3 sessions per week with pomegranate juice, 100 cc, fasting every morning, for 8 weeks. Intervention 4: Control group: Without exercise training and consumption of pomegranate juice. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Babak Rouzbehan
Islamic Azad University of Rasht branch, Taleshan Bridge, Lakan blvd, Raht
Rasht Iran (Islamic Republic of) 351641335 +98 13 3342 3153 rouzbehan@iaurasht.ac.ir Islamic Azad University of Rasht branch scientific Hossein Abed Natanzi
Science and Research Branch, Daneshgah Blvd, Simon Bulivar Blvd, Tehran
Tehran Iran (Islamic Republic of) 1477893855 +98 21 4486 5154 h-abednatanzy@srbiru.ac.ir Islamic Azad University of Tehran Science and Research Branch Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) All Women with Breast Cancer The age range beween 30 and 45 Completion of Treatment courses like Chemotherapy and Radiation 30 years 45 years Female Physiological Menopause at the time of Cancer diagnosis The History of Specialized Treatment like Chemotherapy and Radiation in the last Six Months Performing Cancer-related Surgeries Chronic systematic disease, such as Diabetes and Hypertension Cardiovascular disease such as Heart Failure, Crononary Artery Disorders and severe Hypertension Hormonal abnormalities and immunity disorders Known Mental illness Tobacco and Alcohol use Problems, defects and disease of muscuskeletal system- preventative of Sport activity The history of ongoing Sports exercises before the study begins Cancer cells metastatis and involved of the other Body tissues and Organs C50 Malignant neoplasm of breast Prevention Prevention Prevention N/A Intervention group: aerobic exercise with Stationary Bike, 60 to 90 minutes, 3 sessions per week, for 8 weeks Intervention group: Natural pomegranate juice, 100 cc, fasting every morning, for 8 weeks Intervention group: aerobic exercise and pomegranate juice, 60 to 90 minutes of exercise, 3 sessions per week with pomegranate juice, 100 cc, fasting every morning, for 8 weeks Control group: Without exercise training and consumption of pomegranate juice The percentage of people with decrease in the level of mir-21. Timepoint: 48 hours before the onset and 48 hours after the end of study. Method of measurement: Blood Test. The percentage of people with decrease in the level of mir-155. Timepoint: 48 hours before the onset and 48 hours after the end of study. Method of measurement: Blood Test. The percentage of people with increase in the level of mir-34. Timepoint: 48 hours before the onset and 48 hours after the end of study. Method of measurement: Blood Test. Serum levels of oxidant factor; Malondialdehyde (MDA). Timepoint: 48 hours before the onset and 48 hours after the end of study. Method of measurement: Blood Test. Serum levels of antioxidant factor; Glutathione Peroxidase (GPX). Timepoint: 48 hours before the onset and 48 hours after the end of study. Method of measurement: Blood Test. Serum levels of antioxidant factor; Superoxide Dismutase (SOD). Timepoint: 48 hours before the onset and 48 hours after the end of study. Method of measurement: Blood Test. Islamic Azad University of Rasht branch Approved 2019-12-07 Ethics committee of Qom University University of Qom, Alghadir Blvd., Qom, Iran Qom Ghoum Iran (Islamic Republic of)