IRCT20191230045954N1 IRCT 2021-04-02 Iran University of Medical Sciences Effect of tea tree oil on blepharitis-associated dry eye syndrome TTT (Tea Tree Trial) Tea tree oil effect on blepharitis-associated dry eye syndrome: a double-blind placebo control randomized clinical trial 2020-09-22 anticipated 160 Complete https://irct.ir/trial/50043 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, random allocation to be placed in the tea tree oil group or placebo to receive intervention at the standard time will be done using the permuted balance block randomization technique. According to this issue, the blocks considered in this study will be quadruple blocks. Using STATA software, a random number chain of 1 to 6 will be generated to reach the desired sample size. Considering that the total number of cases for receiving medicine in 4 blocks is 6, if the number produced is more than 6, the next number will be produced without considering it. Preparation of random assignment sequences of drug groups and placing them in sealed envelopes and numbering with a 5-digit serial number will be done by a third party who is not involved in the design of the study. All envelopes have a number The series will be 5 digits, which will be opened immediately after the patients enter the study, and the patients will be divided into two groups, Blinding description: The study is performed in a double-blind manner. Throughout the study, researchers were unaware that each medication and placebo belonged to the group and patients will not be aware of the name of the Medication and its effects. Medication and placebo are prescribed by a doctor outside the research team. 3 Condition 1: Dry eye disease. Condition 2: Blepharitis. Intervention 1: Intervention group: The intervention group received a gel containing 5% tea tree oil for massage on the eyelid twice a day for four weeks. Intervention 2: Control group: The control group receives tea tree oil-free gel every 12 hours (twice a day) which is massaged on the eyelid for four weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information