IRCT20200803048284N1 IRCT 2020-11-04 Kashan University of Medical Sciences Comparison of the effect of Agomelatine and Sertraline on bipolar depression The efficacy comparison of Agomelatin and sertralin on depressive episode, in patients with bipolar I disorder 2020-09-27 anticipated 30 Complete https://irct.ir/trial/50069 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: In our study, the two groups of participants selected by the researcher of the project, and the caregiver and executor are unaware of which group of participants are receiving what kind of medicine, so that after selecting people and dividing them into two groups, the drug The same packages in size and shape, distinguished by the Latin letters A&B, are provided to the participating groups by the caretaker, who is also unaware of the contents of the packages. 3 Bipolar Depression I. Intervention 1: Bipolar I patients who are in a depressive phase and are being treated with Agomelatine are given Agomelatine tablets from Tadbir Kala Pharmaceutical Company at a dose of 25 mg only at bedtime for 8 weeks along with one 500 mg Rahakin tablet from Raha Daroo company or 600 mg (two 300 mg tablets) lithium carbonate from Alhawi Pharmaceutical Company is given orally at bedtime. Intervention 2: Bipolar I patients who are in the depressive phase and are treated with Sertraline are given orally for 8 weeks Sertraline tablets from Dr. Abidi Pharmaceutical Company at a dose of 50 mg daily along with one 500 mg Rahakin tablet from Raha Daroo company or 600 mg (two 300 mg tablets) lithium carbonate from Alhawi Pharmaceutical Company is given orally at bedtime. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more information