]>
IRCT20181212041947N1 IRCT 2020-08-24 Arak University of Medical Sciences effect of Dexmedetomidine, Neostigmin and Ketamin on fibrosis of laminectomy Comparison between the effect of Dexmedetomidine, Neostigmine, and Ketamine coadministered with bupivacaine 0.5% in epidural administration on decreasing of fibrosis after laminectomy 2020-08-05 anticipated 81 Complete https://irct.ir/trial/50076 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Simple individual randomization with randomization with envelopes in 3 groups A and B and C. In this method, we selected a number of cards or letters as an intervention group and the same ‎number of cards for the control group, then the cards were merged. One card was taken out and its ‎allocation was registered and the card was returned to the other cards after leaving. Then the cards ‎are merged again and we remove another card. This process continues to reach a random sequence ‎according to sample size, Blinding description: This study is clinical trial.Outcome elevator and analyzer and participant are blind (double blind).Outcome elevator and analyzer and participant don't aware from grouping. 3 Laminectomy surgery. Intervention 1: Intervention group1:We inject 0.3 milligram in kilogram of ketamine (volume of which is increased to 3 millilitre), is added to 75 mg of Marcaine 0.25 percent. Intervention 2: Intervention group2: We inject 2/5 milligram of Neostigmine (volume of which is increased to 3 millilitre), is added to 75 mg of Marcaine 0.25 percent. Intervention 3: Intervention group3: We inject 1 micro gram in kilogram of Dexmedetomidin (volume of which is increased to 3 millilitre), is added to 75 mg of Marcaine 0.25 percent. Yes - There is a plan to make this available What will be shared: When we publish article in journal When: After the article is published To whom: Researcher in university Conditions: If there are additional questions Where to obtain: Dr alireza Kamali How to obtain: They have to write letters to the professors and the university. Comments: none
public Dr Ali Nazemi Rafie
Valiasr hospital, Valiasr squre
Arak Iran (Islamic Republic of) 3819693345 +98 86 3313 6055 z.khademi@arakmu.ac.ir Arak University of Medical Sciences scientific Dr Alireza Kamali
Research Center, Payambar Azam Complex, Basij square, Sardasht, Arak
Arak Iran (Islamic Republic of) 3819693345 +98 86 3313 6055 a.kamali@arakmu.ac.ir Arak University of Medical Sciences Iran (Islamic Republic of) All patients candidate for Laminectomy surgery All patients with informed consent to participate in the trial All patients with range of age between 25 to 70 years old All patients with Anesthetic ASA class I or II 25 years 70 years Both All patients out of range of age between 25 to 70 years old All patients who were not candidate for Laminectomy surgery All patients with Sensitivity to Dexmedetomidine, Neostigmin and Ketamin All patients with ASA class more than II (III, IV) All female patients in pregnancy or lactation period All patients with uncontrolled psychological disorders M96.1 Postlaminectomy syndrome, not elsewhere classified Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group1:We inject 0.3 milligram in kilogram of ketamine (volume of which is increased to 3 millilitre), is added to 75 mg of Marcaine 0.25 percent. Intervention group2: We inject 2/5 milligram of Neostigmine (volume of which is increased to 3 millilitre), is added to 75 mg of Marcaine 0.25 percent. Intervention group3: We inject 1 micro gram in kilogram of Dexmedetomidin (volume of which is increased to 3 millilitre), is added to 75 mg of Marcaine 0.25 percent. Mean value of thickness of fibrosis due to laminectomy. Timepoint: 3 months after surgery. Method of measurement: Milimeters. Pain. Timepoint: 2, 6, 12 hours after surgery. Method of measurement: Visual analog scale. Arak University of Medical Sciences Approved 2018-10-21 Ethics committee of arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)