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IRCT20200815048408N1 IRCT 2020-08-30 Ahvaz University of Medical Sciences "The effect of peep and fio2 modulation on outcome" Investigating The Effect of Adjustment of Peep and Fio2 Based on Arterial Blood Oxygen Pressure on the Care and Treatment Outcomes of Icu Patients 2020-09-22 anticipated 30 Complete https://irct.ir/trial/50313 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: The study is a pilot and the sample size can be changed, Randomization description: Block random allocation method (5 blocks, each block including 6 patients are selected from both intervention and control groups. The number of possible cases from the arrangement of control and intervention patients is determined by MCMCMC that are not duplicates and 6 cases are randomly selected and to each Block is assigned a state, the first block of patients with hyperoxemia, the second block of patients with hypoxemia and also up to block 4 and the last block four to two of each group is placed in the control and intervention group of 8 patients with hyperoxemia and 7 patients with hypoxemia. N/A Changing the two parameters of peep and fio2 from the ventilator device according to the arterial blood oxygen pressure in the form of hypoxemia and hyperoxemia on the therapeutic outcomes and care of patients admitted to the intensive care unit.. Intervention 1: Intervention group: 15 people in the intervention group, 7 of whom have hypoxemia pao2 <60mmhg and 8 people have hyperoxemia Pao2> 120mmhg, which are randomly divided into 6 blocks.In these two groups in the intervention group, due to arterial blood oxygen pressure, the two parameters of peep and fio2 decrease or increase during 7 days. And according to the sofa criterion, the patient's condition is evaluated. Intervention 2: Control group: 15 patients, including 7 patients with hypoxemia and 8 cases of hyperoxemia, and the parameters of peep and fio2 are routinely adjusted, and the sofa criterion is recorded within 7 days and the patient's condition is checked. Yes - There is a plan to make this available What will be shared: Reports on blood test, sex, age, date of hospitalization, length of hospital stay, underlying disease, ventilator parameters When: "Access period starts 6 months after the results are published" To whom: Employees in universities and researchers Conditions: Help improve the condition of patients admitted to the intensive care unit, help reduce costs, use as a resource for other research. Where to obtain: Email address How to obtain: Have basic scientific information about ventilators Comments:
public Malihe Moghaddas Ghahfarokhi
No. 368, Corner of Bustan 2., Bustan Ave
Khoramshahr Iran (Islamic Republic of) 6417717743 +98 61 5352 3262 Mgh.gh1990@gmail.com Ahvaz University of Medical Sciences scientific Malihe Moghaddas Ghahfarokhi
No. 368, Corner of Bustan 2., Bustan Street
Khoramshahr Iran (Islamic Republic of) ۶۴۱۷۷۱۷۷۴۳ +98 61 5352 3262 mgh.gh1990@gmail.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) Age group 60-18 years Intubation and connection to the ventilator GCS score of at least 6 No lung disease, lung cancer and COPD 18 years 60 years Both Discharge or death of the patient before the intended time for intervention Use of muscle relaxants Post CPR patients Unstable hemodynamics T88.8 Other specified complications of surgical and medical care, not elsewhere classified Treatment - Devices Treatment - Devices Intervention group: 15 people in the intervention group, 7 of whom have hypoxemia pao2 <60mmhg and 8 people have hyperoxemia Pao2> 120mmhg, which are randomly divided into 6 blocks.In these two groups in the intervention group, due to arterial blood oxygen pressure, the two parameters of peep and fio2 decrease or increase during 7 days. And according to the sofa criterion, the patient's condition is evaluated. Control group: 15 patients, including 7 patients with hypoxemia and 8 cases of hyperoxemia, and the parameters of peep and fio2 are routinely adjusted, and the sofa criterion is recorded within 7 days and the patient's condition is checked. Arterial blood oxygen pressure in the form of hypoxemia (Pao2<60mmhg)and hyperoxemia(Pao2>120mmhg). Timepoint: Before the intervention and during 7 days of intervention. Method of measurement: arterial blood gases. Ahvaz University of Medical Sciences Approved 2019-12-29 Ethics committee of Ahwaz University of Medical Sciences No. 368, Corner of Bustan 2., Bustan Street Khoramshahr Khouzestan Iran (Islamic Republic of)