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IRCT201009094719N2 IRCT 2010-12-20 Iranian Astاma Allergy and Immunology Research Institu Effect of synbiotics in treatment of childhood atopic dermatitis Effect of synbiotics in reduction scoring of childhood atopic dermatitis (SCORAD) 2007-01-01 anticipated 40 Complete https://irct.ir/trial/5038 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A atopic dermatitis. Intervention 1: In the intrvention group, children daily took one sachet containing 10 milligram mixture of 1 × 109 CFU/ of seven strain probiotics plus prebiotic (990 milligram fructo-oligosaccharides). We instructed usual treatment of atopic dermatitis including bathing with lukewarm water, moisturing cream (Eucerin) and topical corticosteroid (Hydrocortisone 1%) once time, daily for two month in intervention group. Intervention 2: In the control group, children daily took one sachet for oral use ,containing 1000 milligram sucrose. similarly We instructed usual treatment of atopic dermatitis including bathing with lukewarm water, moisturing cream (Eucerin) and topical corticosteroid (Hydrocortisone 1%) once time, daily for two month in control group.
public Masood Movahedi
Allergy Ward,Chidren Medical Center Hospital, Gharib Street
Tehran Iran (Islamic Republic of) +98 66938545 movahedm@sina.tums.ac.ir Tehran University of Medical Sciences and Health Services scientific Masood Movahedi
Allergy Ward, Chidren Medical Center Hospital, Gharib Street
Tehran Iran (Islamic Republic of) +98 66938545 movahedm@sina.tums.ac.ir Tehran University of Medical Sciences and Health Services Iran (Islamic Republic of) Inclusion criteria were children aged 1–36months with moderate to severe Atopic Dermatitis (SCORAD>25). Exclusion criteria were age less than 1 month and more than 36 months, SCORAD<25, recurrent infections( as an evidence of immunodeficiency), congenital abnormality, chronic disease and problem in eating and administration of systemic corticosteroids. no limit 3 years Both L20 Dermatitis and eczema Treatment - Drugs Treatment - Drugs In the intrvention group, children daily took one sachet containing 10 milligram mixture of 1 × 109 CFU/ of seven strain probiotics plus prebiotic (990 milligram fructo-oligosaccharides). We instructed usual treatment of atopic dermatitis including bathing with lukewarm water, moisturing cream (Eucerin) and topical corticosteroid (Hydrocortisone 1%) once time, daily for two month in intervention group In the control group, children daily took one sachet for oral use ,containing 1000 milligram sucrose. similarly We instructed usual treatment of atopic dermatitis including bathing with lukewarm water, moisturing cream (Eucerin) and topical corticosteroid (Hydrocortisone 1%) once time, daily for two month in control group Sevearity of atopic dermatitis acording to SCORAD. Timepoint: befor and two months after intervention. Method of measurement: SCORAD table. Adverse reaction. Timepoint: every 2 weeks. Method of measurement: asking from parents. Iranian Astاma Allergy and Immunology Research Institu Approved 2008-11-04 Iranian Asthma Allergy and Immunology Ethics Committee Children Medical Center Hospital ,Gharib Street Tehran Iran (Islamic Republic of)