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IRCT20200825048509N1 IRCT 2020-09-19 Yazd University of Medical Sciences Renal function in pulsatile and non-pulsatile perfusion in patient undergoing coronary artery surgery. Review and compare of renal function in pulsatile and non-pulsatile perfusion in patient undergoing coronary artery surgery. 2019-09-23 anticipated 50 Complete https://irct.ir/trial/50514 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Surgeon and the nurse involved in the study were not aware of the kind of perfusion applied to the patient, Blinding description: Surgeon and the nurses involved in the study were not aware of the kind of perfusion applied to the patients. N/A Coronary artery disease. Intervention 1: Intervention group: Group of patients undergoing coronary artery surgery with pulsatile blood flow of pump At the open heart surgery room, after anesthesia and opening the patients chest, patients were connected to the heart-lung mashine and in this study the heart-lung mashine was run in pulsatile blood flow mode in the intervention group, urine and blood samples were collected to measure the related variables to renal function such as: blood sodium and potassium before during and after surgery, Creatinine and BUN before surgery 24 hours after surgery and at releasing time from hospital, urine output before surgery 24 hours after surgery and at releasing time from hospital, and GFR before surgery and at releasing time from hospital. Intervention 2: Control group: Group of patients undergoing coronary artery surgery with non-pulsatile blood flow of pump In this group after connecting to the heart-lung mashine the blood flow was administered non-pulsating and all of the variables related to renal function such as: blood sodium and potassium before during and after surgery, Creatinine and BUN before surgery 24 hours after surgery and at releasing time from hospital, urine output before surgery 24 hours after surgery and at releasing time from hospital, and GFR before surgery and at releasing time from hospital were collected and measured. In order to compare the variable between two groups spss software was used to see if the differences are statistically significant or not. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is no more information
public Sahra Salehi
Bostan Ave, South Valieasr Blv, Baharestan, Isfahan
Isfahan Iran (Islamic Republic of) 8143176944 +98 31 3650 2537 Sahrasalehi90@gmail.com Yazd University of Medical Sciences scientific Sahra Salehi
Bostan Ave, South Valieasr Blv, Baharestan, Isfahan
Isfahan Iran (Islamic Republic of) 8143176944 +98 31 3650 2537 Sahrasalehi90@gmail.com Yazd University of Medical Sciences Iran (Islamic Republic of) Age above 18 years Coronary artery surgery 18 years no limit Both Suffering MI in the last two weeks Off pump surgery Urgent surgery untreated diabetes Abnormal liver function Reduced level of consciousness before surgery I25 Chronic ischemic heart disease Treatment - Devices Treatment - Devices Intervention group: Group of patients undergoing coronary artery surgery with pulsatile blood flow of pump At the open heart surgery room, after anesthesia and opening the patients chest, patients were connected to the heart-lung mashine and in this study the heart-lung mashine was run in pulsatile blood flow mode in the intervention group, urine and blood samples were collected to measure the related variables to renal function such as: blood sodium and potassium before during and after surgery, Creatinine and BUN before surgery 24 hours after surgery and at releasing time from hospital, urine output before surgery 24 hours after surgery and at releasing time from hospital, and GFR before surgery and at releasing time from hospital. Control group: Group of patients undergoing coronary artery surgery with non-pulsatile blood flow of pump In this group after connecting to the heart-lung mashine the blood flow was administered non-pulsating and all of the variables related to renal function such as: blood sodium and potassium before during and after surgery, Creatinine and BUN before surgery 24 hours after surgery and at releasing time from hospital, urine output before surgery 24 hours after surgery and at releasing time from hospital, and GFR before surgery and at releasing time from hospital were collected and measured. In order to compare the variable between two groups spss software was used to see if the differences are statistically significant or not. Change in renal function. Timepoint: Before surgery, during surgery, 24 hours after surgery, at the releasing time from hospital. Method of measurement: Getting blood and urine sample. Yazd University of Medical Sciences Yazd University of Medical Sciences Yazd University of Medical Sciences Approved 2019-07-06 Ethics committee of Yazd Shahid Sadoughi University of medical sciences Bostan Ave, South Valieasr Blv, Baharestan, Isfahan. Yazd Yazd Iran (Islamic Republic of)